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phospho-K63polyUb-hp-IRAK1 [endosome membrane]
Stable Identifier
R-DME-975112
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
endosome membrane
Synonyms
Q05652
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Drosophila melanogaster)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Drosophila melanogaster)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Drosophila melanogaster)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Drosophila melanogaster)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Drosophila melanogaster)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Drosophila melanogaster)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q05652 pll
Gene Names
pll, CG5974
Chain
chain:1-501
Reference Genes
BioGPS Gene:43283 pll
KEGG Gene (Drosophila melanogaster):Dmel_CG5974 pll
Monarch:43283 pll
NCBI Gene:43283 pll
UCSC:Q05652 pll
Reference Transcript
RefSeq:NM_001276079.1 pll
RefSeq:NM_057623.4 pll
Other Identifiers
142881_at
1638252_at
43283
GO:0000166
GO:0002376
GO:0002804
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006915
GO:0007165
GO:0007352
GO:0007526
GO:0008063
GO:0009953
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019904
GO:0023052
GO:0030163
GO:0035172
GO:0035332
GO:0035556
GO:0036211
GO:0043226
GO:0045087
GO:0045732
GO:0046777
GO:0048262
GO:0048583
GO:0048856
GO:0061760
GO:0098542
GO:0106310
GO:0140096
GO:2000060
Participates
as a component of
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Drosophila melanogaster)
Other forms of this molecule
Phospho PLL [cytosol]
PLL [cytosol]
phospho-K63polyUb-hp-IRAK1 [cytosol]
phospho-p-IRAK2 [endosome membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
phospho-p-IRAK2 [plasma membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]
phospho-p-IRAK2 [cytosol]
IRAK4 [cytosol]
Inferred From
K63polyUb-hp-IRAK1 [endosome membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 209 (in Homo sapiens)
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376 (in Homo sapiens)
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387 (in Homo sapiens)
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63polyUb [endosome membrane]) at 134 (in Homo sapiens)
Coordinate
134
Modification
K63polyUb [endosome membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63polyUb [endosome membrane]) at 180 (in Homo sapiens)
Coordinate
180
Modification
K63polyUb [endosome membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001263008.1
,
NP_476971.1
Flybase
FBgn0010441
PRO
Q05652
PDB
1YGO
,
1IK7
,
1D2Z
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22812 tub
1
TUB [cytosol]
(R-DME-206155)
0.927
12
UniProt:O77237
6
Pli [cytosol]
(R-DME-450695)
Pli [cytosol]
(R-DME-450694)
Pli [cytosol]
(R-DME-450696)
phospho-Pli [cytosol]
(R-DME-450825)
phospho-Pli [cytosol]
(R-DME-450815)
phospho-Pli [cytosol]
(R-DME-450806)
0.59
3
UniProt:P15330 dl
13
dl [nucleoplasm]
(R-DME-177676)
dl [cytosol]
(R-DME-168172)
dl [cytosol]
(R-DME-5607652)
dl [cytosol]
(R-DME-1168579)
dl [nucleoplasm]
(R-DME-1168585)
phospho-dl [nucleoplasm]
(R-DME-5624468)
dl [nucleoplasm]
(R-DME-5607656)
phospho-dl [nucleoplasm]
(R-DME-5660642)
dl [nucleoplasm]
(R-DME-4755466)
dl [nucleoplasm]
(R-DME-8865233)
Phospho DL [nucleoplasm]
(R-DME-214731)
Phospho DL [cytosol]
(R-DME-214732)
DL [cytosol]
(R-DME-206011)
0.502
3
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