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Su(dx) [cytosol]
Stable Identifier
R-DME-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
ITCH, Q9Y0H4
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX1 (Drosophila melanogaster)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Drosophila melanogaster)
ITCH polyubiquitinates TP73 (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB binds ITCH (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB:ITCH bind and ubiquitnate GLI1 (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Hedgehog 'on' state (Drosophila melanogaster)
NUMB binds ITCH (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB:ITCH binds GLI1 (Drosophila melanogaster)
GLI1:NUMB:ITCH [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
NUMB:ITCH ubiquitinates GLI1 (Drosophila melanogaster)
GLI1:NUMB:ITCH [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
ub-GLI1:NUMB:ITCH [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
ub-GLI is degraded by the proteasome (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
ub-GLI1:NUMB:ITCH [cytosol] (Drosophila melanogaster)
NUMB:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Signaling by NOTCH (Drosophila melanogaster)
Signaling by NOTCH1 (Drosophila melanogaster)
Activated NOTCH1 Transmits Signal to the Nucleus (Drosophila melanogaster)
ITCH binds DTX (Drosophila melanogaster)
DTX:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
ITCH ubiquitinates DTX (Drosophila melanogaster)
DTX:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
Ub-DTX:ITCH [cytosol] (Drosophila melanogaster)
Su(dx) [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9Y0H4
Gene Names
Su(dx)
Reference Genes
BioGPS Gene:33379 Su(dx)
CTD Gene:33379 Su(dx)
ENSEMBL:FBgn0003557
Flybase:FBgn0003557
KEGG Gene (Drosophila melanogaster):Dmel_CG4244 Su(dx)
Monarch:33379 Su(dx)
NCBI Gene:33379 Su(dx)
UCSC:Q9Y0H4 Su(dx)
Reference Transcript
RefSeq:NM_164449.2 Su(dx)
RefSeq:NM_001272970.1 Su(dx)
RefSeq:NM_164448.2 Su(dx)
RefSeq:NM_001272969.1 Su(dx)
RefSeq:NM_057405.3 Su(dx)
Other Identifiers
142800_at
151689_s_at
1636302_s_at
33379
GO:0000209
GO:0003674
GO:0004842
GO:0005112
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005938
GO:0006464
GO:0006511
GO:0006605
GO:0006622
GO:0006810
GO:0007034
GO:0007165
GO:0007219
GO:0007275
GO:0008150
GO:0008586
GO:0008587
GO:0009056
GO:0015031
GO:0016192
GO:0016348
GO:0016567
GO:0016740
GO:0019915
GO:0031623
GO:0032880
GO:0035209
GO:0043161
GO:0045732
GO:0045746
GO:0045879
GO:0048190
GO:0048856
GO:0050699
GO:0061630
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
input
ITCH binds DTX
NUMB binds ITCH
hasComponent
DTX:ITCH [cytosol]
NUMB:ITCH [cytosol]
Ub-DTX:ITCH [cytosol]
Other forms of this molecule
Su(dx) [cytosol]
Su(dx) [cytosol]
Inferred From
ITCH [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_476753.1
,
NP_001259899.1
,
NP_722753.1
,
NP_722754.1
,
NP_001259898.1
Flybase
FBgn0003557
PRO
Q9Y0H4
PDB
1TK7
,
2JMF
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52485
8
Ubc2 [nucleoplasm]
(R-DME-8864185)
Ubc2 [cytosol]
(R-DME-8864162)
Ubc2 [nucleoplasm]
(R-DME-8864208)
Ubc2 [nucleoplasm]
(R-DME-8852108)
Ubc2 [cytosol]
(R-DME-947633)
Ubc2 [cytosol]
(R-DME-947626)
Ubc2 [nucleoplasm]
(R-DME-174063)
Ubc2 [cytosol]
(R-DME-174100)
0.488
2
UniProt:Q9V3M9 Q9V3M9
0.488
2
UniProt:C6TP34 C6TP34
0.488
2
UniProt:Q9VY93
1
APIP [cytosol]
(R-DME-1237171)
0.488
2
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