Reactome | Rpn13 [nucleoplasm]

Rpn13 [nucleoplasm]

Stable Identifier

R-DME-9918361

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

ADRM1, Q7K2G1

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP base [nucleoplasm] (Drosophila melanogaster)
        
        Rpn13 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7K2G1

Gene Names

Rpn13

Reference Genes

BioGPS Gene:36545 RPN13

ENSEMBL:FBgn0033886

FlyBase:FBgn0033886

KEGG:dme:Dmel_CG13349 RPN13

Monarch:36545 RPN13

NCBI Gene:36545 RPN13

UCSC:Q7K2G1 RPN13

Reference Transcript

Participates

as a component of

19S RP base [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

Rpn13 [cytosol]

Inferred From

ADRM1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_725346.1, NP_001137662.1, NP_001286397.1, NP_001137664.1, NP_610917.1, NP_001137663.1

ENSEMBL

FBtr0087610, FBtr0087611, FBpp0112987, FBgn0033886, FBpp0086737, FBpp0086736, FBtr0114495

FlyBase

FBgn0033886

PRO

Q7K2G1

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9V3I9 Q9V3I9			0.621	3
UniProt:Q7JWV5 Q7JWV5			0.621	3
UniProt:Q9XZ61 Uch-L3	4	UCH-L3 [nucleoplasm] (R-DME-216223) UCH-L3 [cytosol] (R-DME-206189) Uch-L5 [nucleoplasm] (R-DME-5689584) Uch-L5 [cytosol] (R-DME-1629778)	0.621	3
UniProt:Q9V3P6 Rpn2	6	RPN2 [nucleoplasm] (R-DME-216161) RPN2 [cytosol] (R-DME-205706) Rpn2 [extracellular region] (R-DME-6806194) Rpn2 [azurophil granule lumen] (R-DME-6798741) Rpn2 [nucleoplasm] (R-DME-174348) Rpn2 [cytosol] (R-DME-68786)	0.547	2
UniProt:Q94883 Q94883			0.488	2
UniProt:P17789 TTKB			0.488	2
UniProt:Q7JR80 Q7JR80			0.488	2
UniProt:Q9VHJ3	1	E(var)3-9 [nucleoplasm] (R-DME-480506-8)	0.488	2

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