Reactome | mad2l1 [cytosol]

mad2l1 [cytosol]

Stable Identifier

R-DRE-141400

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

MAD2L1, F1QHN1

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - Mitotic Spindle Checkpoint (Danio rerio)
    - Amplification of signal from the kinetochores (Danio rerio)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Danio rerio)
        
        MAD2 associates with the Mad1 kinetochore complex (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Mad1 binds kinetochore (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Release of activated MAD2 from kinetochores (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Danio rerio)
      - Inactivation of APC/C via CDC20 sequestration (Danio rerio)
        
        MAD2*CDC20 complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Danio rerio)
        
        Binding of the MCC complex to the APC/C complex (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Metaphase and Anaphase (Danio rerio)
      - Mitotic Anaphase (Danio rerio)
        
        Separation of Sister Chromatids (Danio rerio)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Separation of sister chromatids (Danio rerio)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
    - Mitotic Prometaphase (Danio rerio)
      - EML4 and NUDC in mitotic spindle formation (Danio rerio)
        
        EML4 recruits NUDC to mitotic spindle (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
      - Resolution of Sister Chromatid Cohesion (Danio rerio)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Kinetochore assembly (Danio rerio)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Danio rerio)
        
        APC-Cdc20 mediated degradation of Nek2A (Danio rerio)
        
        Association of Nek2A with MCC:APC/C (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated Nek2A (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Multiubiquitinated Nek2A [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Multiubiquitination of Nek2A (Danio rerio)
        
        Multiubiquitinated Nek2A [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Danio rerio)
        
        Association of Cyclin A with the APC/C (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Degradation multiubiquitinated Cyclin A (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
      - Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Danio rerio)
        
        Inactivation of APC/C via CDC20 sequestration (Danio rerio)
        
        MAD2*CDC20 complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Danio rerio)
        
        Binding of the MCC complex to the APC/C complex (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases Activate Formins (Danio rerio)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        Mitotic checkpoint complex [cytosol] (Danio rerio)
        
        mad2l1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QHN1

Gene Names

mad2l1

Reference Genes

ENSEMBL:ENSDARG00000004713

Other Identifiers

13240676

550434

A_15_P118709

CJ008238

CJ008239

CUST_21602_PI428451953

CUST_70_PI428451961

DRER03601

Dr.4833.2.S1_at

ENSDART00000028017

ENSDART00000028017_1

ENSDART00000028017_2

GO:0000278

GO:0000776

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0007049

GO:0007059

GO:0007094

GO:0008150

GO:0043226

GO:0051276

GO:0140014

GT_Spec_NM_001017739.1_20911

JP008636

JP008637

LOLS11751

MADDr01007887

NM_001017739

OTTDART00000028651

TC235054

Participates

as an input of

as a component of

as an output of

Release of activated MAD2 from kinetochores (Danio rerio)

Inferred From

MAD2L1 [cytosol] (Homo sapiens)

Activated MAD2L1 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSDARP00000003616, ENSDART00000028017, ENSDARG00000004713

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