Reactome | ywhaq [cytosol]

ywhaq [cytosol]

Stable Identifier

R-DRE-1445105

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

SFN, Q7ZUM0

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - FOXO-mediated transcription (Danio rerio)
      - Regulation of localization of FOXO transcription factors (Danio rerio)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)
        
        YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol] (Danio rerio)
        
        YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Metabolic Genes (Danio rerio)
        
        DDIT4 binds 14-3-3 dimer (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        DDIT4:14-3-3 dimer [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
      - TP53 Regulates Transcription of Cell Cycle Genes (Danio rerio)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Danio rerio)
        
        SFN dimer binds BAX (Danio rerio)
        
        SFN Dimer:BAX [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        SFN dimer binds CDK1 and CCNB1 (Danio rerio)
        
        SFN Dimer:CCNB1:CDK1 [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        SFN dimerizes (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)

Programmed Cell Death (Danio rerio)

- Apoptosis (Danio rerio)
  - Intrinsic Pathway for Apoptosis (Danio rerio)
    - Activation of BH3-only proteins (Danio rerio)
      - Activation of BAD and translocation to mitochondria (Danio rerio)
        
        Sequestration of BAD protein by 14-3-3 (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Danio rerio)
        
        14-3-3 dimer [cytosol] (Danio rerio)
        
        SFN dimer [cytosol] (Danio rerio)
        
        Homologues of SFN [cytosol] (Danio rerio)
        
        ywhaq [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7ZUM0

Gene Names

ywhaq

Reference Genes

BioGPS Gene:399487 ywhaq

CTD Gene:399487 ywhaq

ENSEMBL:ENSDARG00000042539

ENSEMBL:ENSDARG00000042539.4 ywhaq

KEGG Gene (Danio rerio):399487 ywhaq

Monarch:399487 ywhaq

NCBI Gene:399487 ywhaq

Reference Transcript

RefSeq:NM_201513.1 ywhaq

Other Identifiers

13096708

399487

A_15_P113717

A_15_P115434

A_15_P288951

BC066409

CUST_4377_PI428451958

DRER08538

Dr.4609.1.S1_at

Dr.4609.1.S2_at

ENSDART00000062383

ENSDART00000062383_1

ENSDART00000062383_2

GO:0003824

GO:0004497

GO:0005737

GO:0007165

GO:0016491

GO:0023052

LOL00261

LOL01261

LOL01797

LOL03576

LOL03577

LOL05105

LOLS02505

MADDr01005084

NM_201513

OTTDART00000006438

Participates

as a member of

Homologues of SFN [cytosol] (Danio rerio)

Inferred From

SFN [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_958921.1

ZFIN

ZDB-GENE-040122-5

Ensembl

ENSDARG00000042539, ENSDARP00000062382, ENSDART00000062383