Reactome | TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Stable Identifier

R-DRE-166172

Type

Complex

Species

Danio rerio

Compartment

endosome membrane

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Innate Immune System (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
      - MyD88-independent TLR4 cascade (Danio rerio)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Danio rerio)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKBKE (Danio rerio)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Danio rerio)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Danio rerio)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Danio rerio)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Danio rerio)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Danio rerio)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

Inferred From

TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)

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