Reactome | p-T,Y MAPKs [cytosol]

Hemostasis (Danio rerio)

- Platelet activation, signaling and aggregation (Danio rerio)
  - Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
    - Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)
      - F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Growth hormone receptor signaling (Danio rerio)
    - Lyn activates ERK (Danio rerio)
      - p-T,Y MAPKs [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- MAPK family signaling cascades (Danio rerio)
  - MAPK1/MAPK3 signaling (Danio rerio)
    - RAF-independent MAPK1/3 activation (Danio rerio)
      - Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
      - Phosphorylated MAPKs translocate into the nucleus (Danio rerio)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
      - p-T,Y MAPKs dimerize (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
    - RAF/MAP kinase cascade (Danio rerio)
      - MAP2K and MAPK activation (Danio rerio)
        
        MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
        
        MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)
        
        IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
      - Negative regulation of MAPK pathway (Danio rerio)
        
        Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
        
        Negative feedback regulation of MAPK pathway (Danio rerio)
        
        Activated MAPKs phosphorylate MAP2K1 (Danio rerio)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
      - Phosphorylated MAPKs translocate into the nucleus (Danio rerio)
        
        p-T,Y MAPK monomers and dimers [cytosol] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
      - p-T,Y MAPKs dimerize (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by NTRKs (Danio rerio)
    - Signaling by NTRK1 (TRKA) (Danio rerio)
      - Signalling to ERKs (Danio rerio)
        
        Prolonged ERK activation events (Danio rerio)
        
        Frs2-mediated activation (Danio rerio)
        
        MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)
        
        RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)
        
        p-T,Y MAPKs dimerize (Danio rerio)
        
        p-T,Y MAPKs [cytosol] (Danio rerio)