Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-p-S32,S36-NFKBIA [cytosol]
Stable Identifier
R-DRE-177677
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
Q7ZW68
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Downstream signaling events of B Cell Receptor (BCR) (Danio rerio)
Activation of NF-kappaB in B cells (Danio rerio)
Activated IKK phosphorylates I-kappaB (Danio rerio)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Danio rerio)
NF-KappaB p50:p50:p-IKBA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p65:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Danio rerio)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Danio rerio)
NF-KappaB p50:p50:p-IKBA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p65:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Danio rerio)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Danio rerio)
NF-KappaB p50:p50:p-IKBA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p65:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
SCF-beta-TrCP ubiquitinylates IkB (Danio rerio)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Danio rerio)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Danio rerio)
NF-KappaB p50:p50:p-IKBA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p50:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NF-kappaB p65:p65:p-IKB [cytosol] (Danio rerio)
p-IKB alpha,beta,epsilon [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Danio rerio)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Danio rerio)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-1 family signaling (Danio rerio)
Interleukin-1 signaling (Danio rerio)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Danio rerio)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Danio rerio)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
IKBA is phosphorylated by Phospho IKKB kinase (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Danio rerio)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Danio rerio)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Danio rerio)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
C-type lectin receptors (CLRs) (Danio rerio)
CLEC7A (Dectin-1) signaling (Danio rerio)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Danio rerio)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Danio rerio)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Cytosolic sensors of pathogen-associated DNA (Danio rerio)
ZBP1(DAI) mediated induction of type I IFNs (Danio rerio)
RIP-mediated NFkB activation via ZBP1 (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Danio rerio)
TRAF6 mediated NF-kB activation (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated NF-kB activation (Danio rerio)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Danio rerio)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Danio rerio)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF(TICAM1)-mediated TLR4 signaling (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Death Receptor Signalling (Danio rerio)
p75 NTR receptor-mediated signalling (Danio rerio)
p75NTR signals via NF-kB (Danio rerio)
NF-kB is activated and signals survival (Danio rerio)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
IkB is ubiquitinated and degraded (Danio rerio)
Ubiquitinated phospho-IkB [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
phospho-p-S32,S36-NFKBIA [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q7ZW68
Reference Genes
BioGPS Gene:323099
CTD Gene:323099
ENSEMBL:ENSDARG00000007693
KEGG Gene (Danio rerio):323099
Monarch:323099
NCBI Gene:323099
Reference Transcript
RefSeq:NM_199629.1
Other Identifiers
1084892
13044316
323099
A0A2R8RUD4
A_15_P105556
A_15_P169706
A_15_P211791
A_15_P414005
A_15_P664141
A_15_P733966
AAH50175
AAH62524
BC050175
BC062524
BX649530
CJ006178
CJ006179
CJ006180
CJ006181
CJ006440
CJ006441
CJ006442
CJ006443
CJ006687
CJ006688
CJ006689
CJ006690
CJ006950
CJ006951
CJ006952
CJ006953
CJ006998
CJ006999
CJ007000
CJ007001
CJ007610
CJ007611
CJ007612
CJ007613
CJ007760
CJ007761
CJ007762
CJ007763
CJ007860
CJ007861
CJ007862
CJ007863
CJ008085
CJ008086
CJ008087
CJ008088
CJ008261
CJ008262
CJ008263
CJ008264
CJ008704
CJ008705
CJ008706
CJ008707
CJ009681
CJ009682
CJ009683
CJ009684
CJ010153
CJ010154
CJ010155
CJ010156
CJ010365
CJ010366
CJ010367
CJ010368
CJ010455
CJ010456
CJ010457
CJ010458
CJ010941
CJ010942
CJ010943
CJ010944
CJ011068
CJ011069
CJ011070
CJ011071
CUST_4975_PI428451958
Dr.24507.1.S1_at
DRER02019
DRER41744
ENSDARG00000007693
ENSDARP00000015303
ENSDART00000016597
ENSDART00000016597_1
ENSDART00000016597_2
EntrezGene:323099
EntrezGene:nfkbiab
GO:0003674
GO:0005515
GT_Spec_NM_199629.1_57701
IPR002110
IPR020683
IPR036770
JP006576
JP006577
JP006578
JP006579
JP006838
JP006839
JP006840
JP006841
JP007085
JP007086
JP007087
JP007088
JP007348
JP007349
JP007350
JP007351
JP007396
JP007397
JP007398
JP007399
JP008008
JP008009
JP008010
JP008011
JP008158
JP008159
JP008160
JP008161
JP008258
JP008259
JP008260
JP008261
JP008483
JP008484
JP008485
JP008486
JP008659
JP008660
JP008661
JP008662
JP009102
JP009103
JP009104
JP009105
JP010079
JP010080
JP010081
JP010082
JP010551
JP010552
JP010553
JP010554
JP010763
JP010764
JP010765
JP010766
JP010853
JP010854
JP010855
JP010856
JP011339
JP011340
JP011341
JP011342
LOLS03811
MADDr01007050
nfkbiab
nfkbiab-201
NM_199629
NP_955923
OTTDART00000025127
PF12796
PF13606
PR01415
SM00248
UPI000017DEE6
ZDB-GENE-030131-1819
Participant Of
hasComponent
NF-KappaB p50:p50:p-IKBA [cytosol]
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol]
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol]
p-S32,36-IkB-alpha:NF-kB complex [cytosol]
Ubiquitinated phospho-IkB [cytosol]
hasMember
p-IKB alpha,beta,epsilon [cytosol]
input
IkB is ubiquitinated and degraded
output
IKBA is phosphorylated by Phospho IKKB kinase
IKKbeta phosphorylates IkB causing NF-kB to dissociate
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex
Other forms of this molecule
PolyUb-NFKBIA [cytosol]
SUMO1-K21-NFKBIA [nucleoplasm]
NFKBIA [nucleoplasm]
phospho-Ub-21,22-p-S32,S36-NFKBIA [cytosol]
NFKBIA [cytosol]
phospho-K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
Inferred From
p-S32,S36-NFKBIA [cytosol] (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 32 (in Homo sapiens)
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36 (in Homo sapiens)
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_955923.1
© 2019
Reactome
