Reactome | nck1b [cytosol]

nck1b [cytosol]

Stable Identifier

R-DRE-197954

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

NCK1, E7F6M0

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - TCR signaling (Danio rerio)
    - Generation of second messenger molecules (Danio rerio)
      - NCK binds PAK (Danio rerio)
        
        p-SLP-76:NCK1 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        p-SLP-76:NCK:PAK [cytosol] (Danio rerio)
        
        p-SLP-76:NCK1 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - p-SLP-76 binds NCK (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        p-SLP-76:NCK1 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
- Cytokine Signaling in Immune system (Danio rerio)
  - Interferon Signaling (Danio rerio)
    - Antimicrobial mechanism of IFN-stimulated genes (Danio rerio)
      - PKR-mediated signaling (Danio rerio)
        
        NCK1 binds PKR (Danio rerio)
        
        EIF2AK2:NCK1 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
    - Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - Detachment of WASP/WAVE (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - WIP binds WASP,N-WASP, activating them (Danio rerio)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - Downstream signal transduction (Danio rerio)
      - Nck binds to the active PDGF receptor (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
  - Signaling by VEGF (Danio rerio)
    - VEGFA-VEGFR2 Pathway (Danio rerio)
      - CDC42:GTP binds PAK2 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - FYN autophosphorylates (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - FYN phosphorylates PAK2 (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - PAK2 autophorylates (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - PAK2 binds NCK (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds FYN (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds NCK (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - p-Y420-FYN is phosphorylated on S21 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - p38 MAPK activation by VEGFR (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases Activate WASPs and WAVEs (Danio rerio)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        Detachment of WASP/WAVE (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        WIP binds WASP,N-WASP, activating them (Danio rerio)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
    - RHO GTPase cycle (Danio rerio)
      - RHOU GTPase cycle (Danio rerio)
        
        RHOU binds effectors at the plasma membrane (Danio rerio)
        
        RHOU effectors [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Danio rerio)
        
        RHOU effectors [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
      - RHOV GTPase cycle (Danio rerio)
        
        RHOV binds effectors at the plasma membrane (Danio rerio)
        
        RHOV effectors [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Danio rerio)
        
        RHOV effectors [cytosol] (Danio rerio)
        
        nck1b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:E7F6M0

Gene Names

nck1b

Reference Genes

BioGPS Gene:100334953 nck1b

CTD Gene:100334953 nck1b

ENSEMBL:ENSDARG00000075369

KEGG:dre:100334953 nck1b

Monarch:100334953 nck1b

NCBI Gene:100334953 nck1b

UCSC:E7F6M0 nck1b

Reference Transcript

Other Identifiers

100334953

13148664

A_15_P392760

CJ010531

CUST_2960_PI428451953

CUST_2961_PI428451953

DRER17951

DRER32271

DRER33997

Dr.17874.1.A1_at

ENSDART00000109339

GO:0005515

GT_Xhyb_XM_002666595.3_75431

GT_Xhyb_XM_005162521.1_36481

GT_Xhyb_XM_005162522.1_240485

GT_Xhyb_XM_005162523.1_166896

GT_Xhyb_XM_005162524.1_407655

JP010929

XM_690302

ZV700S00002645

Participates

as a candidate of

as an input of

as a component of

as a member of

Inferred From

NCK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_068073236.1, XP_002666641.1

ENSEMBL

ENSDART00000132648, ENSDARG00000075369, ENSDARP00000121375, ENSDARP00000153435, ENSDART00000184346

ZFIN

ZDB-GENE-090317-1

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