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nck1b [cytosol]
Stable Identifier
R-DRE-197954
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
NCK1, E7F6M0
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Danio rerio)
Nephrin family interactions (Danio rerio)
Nephrin binds NCK (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Nephrin mediated activation of N-WASP (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
Netrin-1 signaling (Danio rerio)
DCC mediated attractive signaling (Danio rerio)
Activation of Cdc42 (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Activation of Rac1 (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
DCC interacting NCK-1 (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
RhoGTPase GEF's recruited to DCC (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Interferon Signaling (Danio rerio)
Antiviral mechanism by IFN-stimulated genes (Danio rerio)
PKR-mediated signaling (Danio rerio)
NCK1 binds PKR (Danio rerio)
EIF2AK2:NCK1 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Detachment of WASP/WAVE (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
Nck binds to the active PDGF receptor (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
CDC42:GTP binds PAK2 (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
FYN autophosphorylates (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
FYN phosphorylates PAK2 (Danio rerio)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
PAK2 autophorylates (Danio rerio)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
PAK2 binds NCK (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
p-6Y-VEGFR2 binds FYN (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
p-6Y-VEGFR2 binds NCK (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
p-Y420-FYN is phosphorylated on S21 (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
p38 MAPK activation by VEGFR (Danio rerio)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate WASPs and WAVEs (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Detachment of WASP/WAVE (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
RHO GTPase cycle (Danio rerio)
RHOU GTPase cycle (Danio rerio)
RHOU binds effectors at the plasma membrane (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
RHOU:GTP:RHOU effectors [plasma membrane] (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
RHOV GTPase cycle (Danio rerio)
RHOV binds effectors at the plasma membrane (Danio rerio)
RHOV effectors [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
RHOV:GTP:RHOV effectors [plasma membrane] (Danio rerio)
RHOV effectors [cytosol] (Danio rerio)
nck1b [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:E7F6M0
Gene Names
nck1b
Reference Genes
BioGPS Gene:100334953 nck1b
CTD Gene:100334953 nck1b
ENSEMBL:ENSDARG00000075369
ENSEMBL:ENSDARG00000075369.5 nck1b
KEGG Gene (Danio rerio):100334953 nck1b
Monarch:100334953 nck1b
NCBI Gene:100334953 nck1b
Reference Transcript
RefSeq:XM_002666595.6 nck1b
Other Identifiers
100334953
13148664
A_15_P392760
CJ010531
CUST_2960_PI428451953
CUST_2961_PI428451953
DRER17951
DRER32271
Dr.17874.1.A1_at
ENSDART00000109339
GO:0005737
GO:0005783
GO:0005829
GO:0006417
GO:0007010
GO:0007165
GO:0012501
GO:0016477
GO:0023052
GO:0030838
GO:0030971
GO:0035591
GO:0036211
GO:0036493
GO:0043226
GO:0046875
GO:0048870
GO:0060090
GO:0065003
GO:1902237
GO:1903898
GO:1903912
GT_Xhyb_XM_002666595.3_75431
GT_Xhyb_XM_005162521.1_36481
GT_Xhyb_XM_005162522.1_240485
GT_Xhyb_XM_005162523.1_166896
GT_Xhyb_XM_005162524.1_407655
JP010929
XM_690302
ZV700S00002645
Participates
as a candidate of
RHOV effectors [cytosol] (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
as an input of
NCK1 binds PKR (Danio rerio)
DCC interacting NCK-1 (Danio rerio)
as a component of
EIF2AK2:NCK1 [cytosol] (Danio rerio)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Danio rerio)
as a member of
SH3 domain proteins [cytosol] (Danio rerio)
NCK1,NCK2 [cytosol] (Danio rerio)
Inferred From
NCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_002666641.1
ZFIN
ZDB-GENE-090317-1
Ensembl
ENSDARP00000153435
,
ENSDART00000184346
,
ENSDARG00000075369
,
ENSDARP00000121375
,
ENSDART00000132648
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