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phospho-tsc2 [cytosol]
Stable Identifier
R-DRE-199484
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
p-S939,T1462-TSC2, A0A0G2KHX4
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
AKT phosphorylates TSC2, inhibiting it (Danio rerio)
phospho-tsc2 [cytosol] (Danio rerio)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Danio rerio)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Danio rerio)
phospho-tsc2 [cytosol] (Danio rerio)
phospho-tsc2 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
AKT phosphorylates targets in the cytosol (Danio rerio)
AKT phosphorylates TSC2, inhibiting it (Danio rerio)
phospho-tsc2 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A0A0G2KHX4
Gene Names
tsc2
Reference Genes
BioGPS Gene:567524 tsc2
ENSEMBL:ENSDARG00000103125
KEGG Gene (Danio rerio):567524 tsc2
Monarch:567524 tsc2
NCBI Gene:567524 tsc2
Reference Transcript
RefSeq:NM_001328401.1 tsc2
Other Identifiers
12950952
567524
A_15_P264151
A_15_P543617
A_15_P710101
CJ011323
DRER24127
GO:0003674
GO:0005096
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0030154
GO:0030178
GO:0030234
GO:0032007
GO:0032991
GO:0033596
GO:0043226
GO:0043547
GO:0046627
GO:0048856
GO:0051056
GO:0051726
GO:0051898
GO:0060575
GO:0099608
GT_Spec_XM_003197738.2_293805
GT_Spec_XM_690820.6_331055
XM_689711
XM_690820
Participant Of
input
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
hasComponent
p-S939,T1462-TSC2:14-3-3 dimer [cytosol]
output
AKT phosphorylates TSC2, inhibiting it
Other forms of this molecule
phospho-tsc2 [cytosol]
tsc2 [cytosol]
phospho-tsc2 [cytosol]
Inferred From
p-S939,T1462-TSC2 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 939 (in Homo sapiens)
Coordinate
939
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 1462 (in Homo sapiens)
Coordinate
1462
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001315330.1
Ensembl
ENSDART00000158948
,
ENSDARP00000131915
,
ENSDARG00000103125
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