Reactome | itk [cytosol]

itk [cytosol]

Stable Identifier

R-DRE-202319

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ITK, F1R3M1

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - TCR signaling (Danio rerio)
    - Generation of second messenger molecules (Danio rerio)
      - Phosphorylation of PLC-gamma1 (Danio rerio)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Danio rerio)
        
        itk [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Fc epsilon receptor (FCERI) signaling (Danio rerio)
    - FCERI mediated Ca+2 mobilization (Danio rerio)
      - Phosphorylation of TEC kinases by p-SYK (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Danio rerio)
        
        TEC,BTK,ITK,(TXK) [cytosol] (Danio rerio)
        
        itk [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F1R3M1

Gene Names

itk

Reference Genes

ENSEMBL:ENSDARG00000017565

Other Identifiers

13016138

798906

A_15_P112532

A_15_P286756

CUST_11697_PI428451953

CUST_4082_PI428451958

DRER00342

Dr.596.1.S1_at

ENSDART00000003993

ENSDART00000003993_1

ENSDART00000003993_2

GO:0000166

GO:0001865

GO:0002250

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0006464

GO:0006468

GO:0007165

GO:0008150

GO:0016301

GO:0016310

GO:0016740

GO:0030154

GO:0035556

GO:0038083

GO:0043167

GO:0046872

GO:0048856

GO:0050852

GO:0050853

GT_Xhyb_NM_131104.1_151036

GT_Xhyb_XM_005173267.1_361895

LOLS00342

MADDr01014263

NM_131104

OTTDART00000026838

XM_683882

Participant Of

hasMember

TEC,BTK,ITK,(TXK) [cytosol]

hasComponent

ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]

Other forms of this molecule

phospho-itk [cytosol]

Inferred From

ITK [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSDART00000003993, ENSDARP00000022015, ENSDARG00000017565

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