Reactome | col1a1a [extracellular region]

col1a1a [extracellular region]

Stable Identifier

R-DRE-2089980

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL1A1, F1QJC9

Locations in the PathwayBrowser

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Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Assembly of collagen fibrils and other multimeric structures (Danio rerio)
    - Crosslinking of collagen fibrils (Danio rerio)
      - Formation of allysine by LOX (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with allysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without allysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with allysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without allysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of dehydro-lysinonorleucine cross-links (Danio rerio)
        
        Collagen type 1 fibrils cross-linked by dehydro-lysinonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with dehydro-lysinonorleucine [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without deH-LNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with allysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without allysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of histidino-hydroxylysinonorleucine cross-links (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with histidino-hydroxylysinoleucine cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of hydroxyallysine by LOX (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with hydroxylysyl-pyridinoline cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxylysyl-pyridinoline cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without HL-Pyr [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with hydroxylysyl-pyrrole cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxylysyl-pyrrole cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without HL-Pyrrole [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of lysino-5-ketonorleucine cross-links (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of lysyl-pyridinoline cross-links (Danio rerio)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with lysyl-pyridinoline cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with lysyl-pyridinoline cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without L-Pyr [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Formation of lysyl-pyrrole cross-links (Danio rerio)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        Collagen type I fibril with lysyl-pyrrole cross-links [extracellular region] (Danio rerio)
        
        Tropocollagen type I with or without L-Pyrrole [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Formation of collagen fibres (Danio rerio)
      - Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type I fibre [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Formation of collagen fibrils (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)
      - Collagen type I, II fibrils [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Collagen type I,II:XII,XIV fibrils [extracellular region] (Danio rerio)
        
        Collagen type I, II fibrils [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - Removal of fibrillar collagen C-propeptides (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Degradation of the extracellular matrix (Danio rerio)
  - Collagen degradation (Danio rerio)
    - Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type I degradation by MMP15 (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- ECM proteoglycans (Danio rerio)
  - BGN binds Collagen types I, VI, (IX) (Danio rerio)
    - BGN:Collagen types I, VI, (IX) [extracellular region] (Danio rerio)
      - Collagen types I, VI, (IX) [extracellular region] (Danio rerio)
        
        Collagen type I fibre [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen types I, VI, (IX) [extracellular region] (Danio rerio)
      - Collagen type I fibre [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)
    - COMP interactors [extracellular region] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - COMP pentamer:COMP interactors [extracellular region] (Danio rerio)
      - COMP interactors [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - DCN binds collagen I, II, III, VI fibrils (Danio rerio)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)
    - Collagen type I fibril [extracellular region] (Danio rerio)
      - Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Integrin cell surface interactions (Danio rerio)
  - Collagen type I binds integrin alpha11beta1 (Danio rerio)
    - Collagen type I fibril [extracellular region] (Danio rerio)
      - Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Non-integrin membrane-ECM interactions (Danio rerio)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Danio rerio)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

Hemostasis (Danio rerio)

- Cell surface interactions at the vascular wall (Danio rerio)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Danio rerio)
    - Collagen type I fibril [extracellular region] (Danio rerio)
      - Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Platelet Adhesion to exposed collagen (Danio rerio)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Danio rerio)
    - Collagen type I fibril [extracellular region] (Danio rerio)
      - Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)
    - Collagen type I fibril:vWF [extracellular region] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
      - Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - vWF binds to collagen (Danio rerio)
    - Collagen type I fibril [extracellular region] (Danio rerio)
      - Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type I fibril:vWF [extracellular region] (Danio rerio)
      - Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Platelet activation, signaling and aggregation (Danio rerio)
  - GP1b-IX-V activation signalling (Danio rerio)
    - GP1b signaling involves c-Src (Danio rerio)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GP1b-IX-V binds 14-3-3-zeta (Danio rerio)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Danio rerio)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GP1b-IX-V binds filamin (Danio rerio)
      - GPIb-IX-V:vWF:filamin-A [plasma membrane] (Danio rerio)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Danio rerio)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Danio rerio)
        
        GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Danio rerio)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Danio rerio)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Danio rerio)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - GPVI-mediated activation cascade (Danio rerio)
    - Binding of Syk tyrosine kinase (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Danio rerio)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Danio rerio)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - GPVI stimulates PI3K beta, gamma (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Danio rerio)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - SYK autophosphorylates (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Danio rerio)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Danio rerio)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - p-Y348-SYK dissociates (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Danio rerio)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - Platelet Aggregation (Plug Formation) (Danio rerio)
    - Thrombin binding to GP1b:IX:V (Danio rerio)
      - GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Danio rerio)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Danio rerio)
        
        Collagen type I fibril:vWF [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by MET (Danio rerio)
    - MET promotes cell motility (Danio rerio)
      - MET activates PTK2 signaling (Danio rerio)
        
        PTK2 binds activated MET (Danio rerio)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Danio rerio)
        
        Collagen, laminin, fibronectin [extracellular region] (Danio rerio)
        
        Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type I fibre [extracellular region] (Danio rerio)
        
        Collagen type I fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type I [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QJC9

Gene Names

col1a1a

Reference Genes

ENSEMBL:ENSDARG00000012405

Other Identifiers

13166568

13279772

337158

A_15_P106798

A_15_P133341

A_15_P222811

A_15_P592937

A_15_P629251

A_15_P751356

BC063249

CJ006895

CJ006897

CJ006898

CJ006899

CJ009870

CJ009872

CJ009873

CJ009874

CJ013970

CUST_17441_PI428451953

CUST_17442_PI428451953

CUST_42_PI399344711

DRER01074

DRER05719

DRER39418

Dr.20097.1.S1_s_at

DrAffx.2.1.S1_s_at

ENSDART00000009393

ENSDART00000009393_1

ENSDART00000009393_2

GO:0001501

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006950

GO:0008150

GO:0021700

GO:0030198

GO:0030278

GO:0031012

GO:0031101

GO:0033333

GO:0033334

GO:0033339

GO:0035630

GO:0040007

GO:0043167

GO:0046849

GO:0046872

GO:0048856

JP007293

JP007295

JP007296

JP007297

JP010268

JP010270

JP010271

JP010272

LOLS01020

NM_199214

OTTDART00000024399

Participant Of

hasComponent

Tropocollagen type I [extracellular region]

Other forms of this molecule

col1a1a [endoplasmic reticulum lumen]

col1a1a [extracellular region]

Inferred From

3x4Hyp-3Hyp-GalHyl-COL1A1 [extracellular region] (Homo sapiens)

Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

Ensembl

ENSDARP00000003177, ENSDART00000009393, ENSDARG00000012405

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