Reactome | VAMP2 [plasma membrane]

VAMP2 [plasma membrane]

Stable Identifier

R-DRE-210516

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

Q7SZZ5

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Other interleukin signaling (Danio rerio)
      - TXLNA (IL14) binds syntaxin1A (Danio rerio)
        
        STXA1:SNAP25,STXBP2, VAMP2 [plasma membrane] (Danio rerio)
        
        SNAP25,STXBP2, VAMP2 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
      - CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
      - PICALM binds R-SNAREs (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - Clathrin recruits PIK3C2A (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2 [plasma membrane] (Danio rerio)
  - trans-Golgi Network Vesicle Budding (Danio rerio)
    - Vamp2 associated secretory vesicle to plasma membrane transport (Danio rerio)
      - VAMP2 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7SZZ5

Reference Genes

BioGPS Gene:336281

ENSEMBL:ENSDARG00000056877

KEGG Gene (Danio rerio):336281

Monarch:336281

NCBI Gene:336281

Reference Transcript

RefSeq:NM_200005.1

Other Identifiers

1077506

12968406

336281

A_15_P113253

A_15_P119559

A_15_P236271

AAH59626

AL807389

BC059626

DRER11455

ENSDARG00000056877

ENSDARP00000073910

ENSDART00000079454

ENSDART00000079454_1

ENSDART00000079454_2

EntrezGene:336281

EntrezGene:vamp2

GO:0005575

GO:0005623

GO:0005886

GO:0006810

GO:0008150

GO:0016020

GO:0016021

GO:0016192

GO:0031982

GO:0032154

GO:0043226

GT_Spec_NM_200005.1_34681

IPR001388

IPR016444

LOLS14897

MADDr01004886

NM_200005

NP_956299

OTTDART00000002302

PF00957

PR00219

UPI00001B661B

vamp2

vamp2-201

ZDB-GENE-030131-8225

Participant Of

hasMember

VAMP2,3,8 [plasma membrane]

output

Vamp2 associated secretory vesicle to plasma membrane transport

hasCandidate

SNAP25,STXBP2, VAMP2 [plasma membrane]

hasComponent

SNARE complex [plasma membrane]

Other forms of this molecule

VAMP2 [clathrin-coated endocytic vesicle membrane]

VAMP2 [secretory granule membrane]

VAMP2 [cytoplasmic vesicle membrane]

VAMP2 [Golgi membrane]

VAMP2 [lysosomal membrane]

VAMP2 [cytosol]

VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]

VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]

Inferred From

VAMP2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_956299.1