Reactome | col1a1a [extracellular region]

col1a1a [extracellular region]

Stable Identifier

R-DRE-2127352-2

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

GlcGalHyl-COL3A1(154-1241), F1QJC9

Locations in the PathwayBrowser

Expand all

Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - NCAM signaling for neurite out-growth (Danio rerio)
      - NCAM1 interactions (Danio rerio)
        
        Interaction of NCAM1 with collagens (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
        
        NCAM-1:Collagen complex [plasma membrane] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Assembly of collagen fibrils and other multimeric structures (Danio rerio)
    - Formation of collagen fibres (Danio rerio)
      - Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type III fibre [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Formation of collagen fibrils (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - Removal of fibrillar collagen C-propeptides (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Degradation of the extracellular matrix (Danio rerio)
  - Collagen degradation (Danio rerio)
    - Collagen type III degradation by MMP1,8,9,13 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type III degradation by MMP14 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type III degradation by MMP15 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- ECM proteoglycans (Danio rerio)
  - DCN binds collagen I, II, III, VI fibrils (Danio rerio)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - VTN binds collagens II, III and V (Danio rerio)
    - Collagen types II, III, V [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - VTN:Collagen types II,III,V [extracellular region] (Danio rerio)
      - Collagen types II, III, V [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Integrin cell surface interactions (Danio rerio)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Danio rerio)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Danio rerio)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Non-integrin membrane-ECM interactions (Danio rerio)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Danio rerio)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by MET (Danio rerio)
    - MET promotes cell motility (Danio rerio)
      - MET activates PTK2 signaling (Danio rerio)
        
        PTK2 binds activated MET (Danio rerio)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Danio rerio)
        
        Collagen, laminin, fibronectin [extracellular region] (Danio rerio)
        
        Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type III fibre [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - PDGF binds to extracellular matrix proteins (Danio rerio)
      - Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - PDGF A and B chains:ECM complex [extracellular region] (Danio rerio)
        
        Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QJC9

Gene Names

col1a1a

Reference Genes

ENSEMBL:ENSDARG00000012405

Other Identifiers

13166568

13279772

337158

A_15_P106798

A_15_P133341

A_15_P222811

A_15_P592937

A_15_P629251

A_15_P751356

BC063249

CJ006895

CJ006897

CJ006898

CJ006899

CJ009870

CJ009872

CJ009873

CJ009874

CJ013970

CUST_17441_PI428451953

CUST_17442_PI428451953

CUST_42_PI399344711

DRER01074

DRER05719

DRER39418

Dr.20097.1.S1_s_at

DrAffx.2.1.S1_s_at

ENSDART00000009393

ENSDART00000009393_1

ENSDART00000009393_2

GO:0001501

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006950

GO:0008150

GO:0021700

GO:0030198

GO:0030278

GO:0031012

GO:0031101

GO:0033333

GO:0033334

GO:0033339

GO:0035630

GO:0040007

GO:0043167

GO:0046849

GO:0046872

GO:0048856

JP007293

JP007295

JP007296

JP007297

JP010268

JP010270

JP010271

JP010272

LOLS01020

NM_199214

OTTDART00000024399

Participant Of

hasMember

Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region]

Other forms of this molecule

col1a1a [endoplasmic reticulum lumen]

col1a1a [extracellular region]

Inferred From

GlcGalHyl-COL3A1(154-1241) [extracellular region] (Homo sapiens)

Modified Residues

Name

O5-glucosylgalactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-glucosylgalactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine.

Cross References

Ensembl

ENSDART00000009393, ENSDARG00000012405, ENSDARP00000003177

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