Reactome | col8a1a [endoplasmic reticulum lumen]

col8a1a [endoplasmic reticulum lumen]

Stable Identifier

R-DRE-2173143

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

endoplasmic reticulum lumen

Synonyms

3x4Hyp-5Hyl-COL8A1(28-744), B0S5W0

Locations in the PathwayBrowser

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Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)
      - COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
      - Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Collagen chain trimerization (Danio rerio)
      - Association of procollagen type VIII (Danio rerio)
        
        Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type VIII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Danio rerio)
      - PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)
      - COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)
      - Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
      - Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)
      - Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
      - PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)
      - Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Procollagen triple helix formation (Danio rerio)
      - Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Danio rerio)
        
        Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        Non-fibrillar collagens [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type VIII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
      - Procollagen C-linked trimers [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type VIII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Secretion of collagens (Danio rerio)
      - Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Danio rerio)
        
        Collagens and tropocollagens [endoplasmic reticulum lumen] (Danio rerio)
        
        Non-fibrillar collagens [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type VIII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)
        
        col8a1a [endoplasmic reticulum lumen] (Danio rerio)

External Reference Information

External Reference

UniProt:B0S5W0

Gene Names

col8a1a

Reference Genes

ENSEMBL:ENSDARG00000077403

ENSEMBL:ENSDARG00000111174 col8a1a

Other Identifiers

13260636

557795

AI397462_R

A_15_P598152

A_15_P628286

CUST_4649_PI428451958

DRER16257

Dr.20245.1.A1_at

ENSDART00000102981

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0008150

GO:0009790

GO:0014028

GO:0030198

GO:0030903

GO:0031012

GO:0048570

GO:0048646

GO:0048856

GO:0060322

GT_Spec_NM_001142374.1_63801

LOLS14682

MADDr01013604

XM_680918

Participates

as a member of

Homologues of 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Danio rerio)

Other forms of this molecule

col8a1a [endoplasmic reticulum lumen]

col8a1a [extracellular region]

Inferred From

3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,5R)-5-hydroxylysine at unknown position

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Cross References

Ensembl

ENSDART00000102981, ENSDARP00000093755, ENSDARG00000077403, ENSDART00000185526, ENSDARP00000154044, ENSDARG00000111174