Reactome | dnm2a [cytosol]

dnm2a [cytosol]

Stable Identifier

R-DRE-2213180

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

DNM2, A0A0R4IIR1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DNM:GDP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        DNM:GTP [cytosol] (Danio rerio)
        
        Dynamin [cytosol] (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
  - trans-Golgi Network Vesicle Budding (Danio rerio)
    - Golgi Associated Vesicle Biogenesis (Danio rerio)
      - trans-Golgi Network Vesicle Scission (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)
    - Lysosome Vesicle Biogenesis (Danio rerio)
      - trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)
        
        dnm2a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A0R4IIR1

Gene Names

dnm2a

Reference Genes

BioGPS Gene:559334 dnm2a

CTD Gene:559334 dnm2a

ENSEMBL:ENSDARG00000069937

Monarch:559334 dnm2a

NCBI Gene:559334 dnm2a

Reference Transcript

RefSeq:XM_005164241.3 dnm2a

Other Identifiers

13169928

559334

A_15_P118330

A_15_P154121

A_15_P266281

CUST_27109_PI428451953

DRER03086

DRER31156

ENSDART00000024031

ENSDART00000024031_2

GO:0000166

GO:0000266

GO:0003374

GO:0003674

GO:0003924

GO:0005525

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005856

GO:0005874

GO:0005886

GO:0006810

GO:0006897

GO:0007005

GO:0008017

GO:0008092

GO:0008150

GO:0009790

GO:0014069

GO:0015031

GO:0015630

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0022607

GO:0030424

GO:0031410

GO:0031623

GO:0031966

GO:0043009

GO:0043167

GO:0043197

GO:0043226

GO:0044327

GO:0045202

GO:0045211

GO:0048285

GO:0048856

GO:0050803

GO:0060026

GO:0061024

GO:0061025

GO:0061053

GO:0061061

GO:0065003

GO:0098793

GO:0098844

GO:0098884

OTTDART00000028002

Participant Of

output

hasMember

Dynamin [cytosol]

Other forms of this molecule

dnm2a [Golgi membrane]

dnm2a [lysosomal membrane]

dnm2a [endocytic vesicle membrane]

dnm2a [plasma membrane]

Inferred From

DNM2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005164298.1

Ensembl

ENSDARG00000069937, ENSDARP00000134807, ENSDART00000165100

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