Reactome | traf6 [cytosol]

traf6 [cytosol]

Stable Identifier

R-DRE-2685681

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

K63polyUb-TRAF6, Q6IWL4

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - TCR signaling (Danio rerio)
    - Downstream TCR signaling (Danio rerio)
      - Activation of IKK complex (Danio rerio)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Activation of TAK1-TAB2 complex (Danio rerio)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Auto-ubiquitination of TRAF6 (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Ubiquitination of NEMO by TRAF6 (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-1 family signaling (Danio rerio)
      - Interleukin-1 signaling (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        Polyubiquitinated TRAF6 binds the TAK1 complex (Danio rerio)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 is activated within the TAK1 complex (Danio rerio)
        
        hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TRAF6 is K63 poly-ubiquitinated (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Interleukin-17 signaling (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Alpha-protein kinase 1 signaling pathway (Danio rerio)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Danio rerio)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Danio rerio)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Danio rerio)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
  - C-type lectin receptors (CLRs) (Danio rerio)
    - CLEC7A (Dectin-1) signaling (Danio rerio)
      - K63polyUb-TAK1 autophosphorylates (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - K63polyUb-TRAF6 ubiquitinates TAK1 (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - TRAF6 oligomer autoubiquitinates (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - TRIKA2 binds K63polyUb-TRAF6 oligomer (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Danio rerio)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Danio rerio)
        
        K63polyUb-TRAF6 oligomer [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Ubiquitination of NEMO by TRAF6 (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
  - Fc epsilon receptor (FCERI) signaling (Danio rerio)
    - FCERI mediated NF-kB activation (Danio rerio)
      - Activation of TAK1 complex bound to pUb-TRAF6 (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Danio rerio)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Auto-ubiquitination of TRAF6 (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Danio rerio)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Phosphorylation of IKK-beta by TAK1 (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Danio rerio)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Danio rerio)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Danio rerio)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Danio rerio)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Ubiquitination of NEMO by TRAF6 (Danio rerio)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Danio rerio)
    - NOD1/2 Signaling Pathway (Danio rerio)
      - Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
      - Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
      - MyD88-independent TLR4 cascade (Danio rerio)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TRAF6-mediated induction of TAK1 complex within TLR4 complex (Danio rerio)
        
        Activation of TAK1 complex bound to activated TLR4 complex (Danio rerio)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Danio rerio)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Danio rerio)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
    - Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Danio rerio)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Danio rerio)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Danio rerio)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Death Receptor Signalling (Danio rerio)
  - p75 NTR receptor-mediated signalling (Danio rerio)
    - p75NTR signals via NF-kB (Danio rerio)
      - p75NTR recruits signalling complexes (Danio rerio)
        
        TRAF6 is auto-ubiquitinated (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Danio rerio)
        
        traf6 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6IWL4

Gene Names

traf6

Reference Genes

BioGPS Gene:554561 traf6

ENSEMBL:ENSDARG00000028058

KEGG Gene (Danio rerio):554561 traf6

Monarch:554561 traf6

NCBI Gene:554561 traf6

Reference Transcript

RefSeq:NM_001044752.1 traf6

Other Identifiers

13239599

554561

CJ003403

CJ003404

CJ003405

CJ003406

CJ007623

CJ007625

CJ007626

CJ007627

CJ007903

CJ007905

CJ007906

CJ007907

CJ009478

CJ009480

CJ009481

CJ009482

CJ009845

CJ009847

CJ009848

CJ009849

CJ010296

CJ010298

CJ010299

CJ010300

CJ010351

CJ010353

CJ010354

CJ010355

CJ010826

CJ010828

CJ010829

CJ010830

CJ010913

CJ010915

CJ010916

CJ010917

CJ011159

CJ011163

CJ011164

CJ011165

CJ012157

CJ012159

CJ012160

CJ012161

CJ013846

CJ014444

CJ014507

CUST_1753_PI424165564

CUST_1754_PI424165564

CUST_1755_PI424165564

CUST_1756_PI424165564

CUST_1757_PI424165564

CUST_1758_PI424165564

CUST_1759_PI424165564

CUST_1760_PI424165564

DRER04600

Dr.15109.1.A1_at

ENSDART00000038273

ENSDART00000038273_1

ENSDART00000038273_2

GO:0002376

GO:0003674

GO:0004842

GO:0005164

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0006464

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0008270

GO:0009058

GO:0009615

GO:0009617

GO:0016567

GO:0016740

GO:0030593

GO:0033209

GO:0034641

GO:0038061

GO:0040011

GO:0042981

GO:0043122

GO:0043167

GO:0045087

GO:0045893

GO:0046330

GO:0046872

GO:0048870

GO:0070498

GO:0070534

GT_Spec_NM_001044752.1_250525

JP003802

JP003803

JP003804

JP003805

JP008021

JP008023

JP008024

JP008025

JP008301

JP008303

JP008304

JP008305

JP009876

JP009878

JP009879

JP009880

JP010243

JP010245

JP010246

JP010247

JP010694

JP010696

JP010697

JP010698

JP010749

JP010751

JP010752

JP010753

JP011224

JP011226

JP011227

JP011228

JP011311

JP011313

JP011314

JP011315

LOL04625

LOL04626

LOL04627

LOL04628

LOL04629

LOL04630

LOL04631

LOL04674

LOL04677

LOL04678

MADDr01007398

NM_001044752

OTTDART00000013635

TC252424

XM_692005

Participant Of

hasComponent

hasMember

K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]

repeatedUnit

K63polyUb-TRAF6 oligomer [cytosol]

Other forms of this molecule

traf6 [cytosol]

traf6 [endosome membrane]

traf6 [plasma membrane]

traf6 [cytosol]

Inferred From

K63polyUb-TRAF6 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124 (in Homo sapiens)

Coordinate

124

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001038217.1

Ensembl

ENSDART00000180847, ENSDART00000038273, ENSDARG00000028058, ENSDARP00000151579, ENSDART00000191675, ENSDARP00000036715, ENSDARP00000150477

PRO

Q6IWL4

PDB

6MYD, 5VO0, 5VNZ

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