Reactome | mkp3 [nucleoplasm]

mkp3 [nucleoplasm]

Stable Identifier

R-DRE-2871619

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

DUSP6, Q7T2L8

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-17 signaling (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
      - Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
      - Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
      - MyD88-independent TLR4 cascade (Danio rerio)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by NTRKs (Danio rerio)
    - Signaling by NTRK1 (TRKA) (Danio rerio)
      - Nuclear Events (kinase and transcription factor activation) (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        mkp3 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7T2L8

Gene Names

mkp3

Reference Genes

BioGPS Gene:353314 mkp3

ENSEMBL:ENSDARG00000070914

ENSEMBL:ENSDARG00000070914.4 mkp3

ENSEMBL:ENSDARG00000116888.1 mkp3

KEGG Gene (Danio rerio):353314 mkp3

Monarch:353314 mkp3

NCBI Gene:353314 mkp3

Reference Transcript

RefSeq:NM_194380.1 mkp3

Other Identifiers

13161326

353314

AY278203.1

A_15_P105344

BC060937

BC067381

CJ003928

CJ012616

CJ012928

CJ013110

CJ013827

CUST_1263_PI428451958

DRER16788

DRER33314

Dr.16301.2.A1_at

ENSDART00000104496

ENSDART00000104496_1

ENSDART00000104496_2

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005737

GO:0005829

GO:0006470

GO:0008138

GO:0008330

GO:0009953

GO:0012501

GO:0016301

GO:0016310

GO:0016311

GO:0016740

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0023052

GO:0030154

GO:0033550

GO:0036211

GO:0040036

GO:0042663

GO:0043065

GO:0048856

GO:0060420

GO:0070373

GO:0140096

GO:1905179

GT_Xhyb_NM_194380.1_291535

GT_Xhyb_XM_005162999.1_365385

JP004327

LOL00317

LOL01317

LOL01853

LOL03880

LOL03881

LOL03882

LOL03883

LOL03885

LOL03886

LOL05160

LOLS13552

LOLT00029

MADDr01007901

NM_194380

OTTDART00000026849

XM_679740

Participates

as a member of

ERK-specific DUSP [nucleoplasm] (Danio rerio)

Other forms of this molecule

mkp3 [cytosol]

Inferred From

DUSP6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_919361.1

ZFIN

ZDB-GENE-030613-1

Ensembl

ENSDARP00000148588, ENSDARG00000116888, ENSDARP00000095269, ENSDARG00000070914, ENSDART00000104496, ENSDART00000181820

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