Reactome | YES1 [cytosol]

YES1 [cytosol]

Stable Identifier

R-DRE-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

A1A5H8

Locations in the PathwayBrowser

Expand all

Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - EPH-Ephrin signaling (Danio rerio)
      - EPH-ephrin mediated repulsion of cells (Danio rerio)
        
        SFKs phosphorylate VAV2,3 (Danio rerio)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Danio rerio)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Danio rerio)
        
        SRC,FYN,YES,LYN [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Danio rerio)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Danio rerio)
        
        SRC,FYN,YES,LYN [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        SRC,FYN,YES,LYN [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Danio rerio)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Danio rerio)
        
        SRC,FYN,YES,LYN [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Danio rerio)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Danio rerio)
        
        SRC,FYN,YES,LYN [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - EPHA-mediated growth cone collapse (Danio rerio)
        
        NGEF exchanges GTP for GDP on RHOA (Danio rerio)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Danio rerio)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Danio rerio)
        
        SRC,FYN,YES,LYN [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
      - Regulation of signaling by CBL (Danio rerio)
        
        CBL ubiquitinates PI3K (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        FYN-like kinases [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        FYN-like kinases [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
        
        FYN-like kinases [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        FYN-like kinases [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by SCF-KIT (Danio rerio)
    - Dimerization of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Disassociation and translocation of STATs to the nucleus (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - JAK2 binds to p-KIT (Danio rerio)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Phosphorylation of JAK2 (Danio rerio)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Phosphorylation of SHP2 by SFKs (Danio rerio)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Phosphorylation of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Recruitment of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Regulation of KIT signaling (Danio rerio)
      - Phosphorylation of APS (Danio rerio)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
      - Recruitment of CBL to KIT (Danio rerio)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)
    - Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        YES1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A1A5H8

Reference Genes

BioGPS Gene:407620

ENSEMBL:ENSDARG00000005941

KEGG Gene (Danio rerio):407620

Monarch:407620

NCBI Gene:407620

Reference Transcript

RefSeq:NM_001013270.3

Other Identifiers

13082074

13278218

407620

A_15_P101191

A_15_P107924

A_15_P110140

A_15_P334829

CJ003297

CJ003298

CJ012416

CUST_3942_PI428451958

DRER03486

DRER29584

Dr.16586.1.A1_at

Dr.3409.1.A1_at

ENSDART00000027090

ENSDART00000027090_1

ENSDART00000027090_2

GO:0003824

GO:0004672

GO:0004713

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0006468

GO:0016740

GO:0036211

GO:0043226

GO:0051787

GO:0140096

GT_Spec_NM_001013270.3_38072

JP003667

JP003668

LOLS03503

LOLS06226

MADDr01010390

NM_001013270

OTTDART00000024475

TC259346

Participates

as a candidate of

FYN-like kinases [cytosol] (Danio rerio)

as a member of

Other forms of this molecule

phospho-MyrG-p-Y426-YES1 [plasma membrane]

Inferred From

YES1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001013288.2

IntEnz

2.7.10.2

ZFIN

ZDB-GENE-050126-1

Ensembl

ENSDART00000027090, ENSDARP00000009659, ENSDARP00000144472, ENSDART00000178066, ENSDARG00000005941

PRO

A1A5H8

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