Reactome | CRFB6 [plasma membrane]

CRFB6 [plasma membrane]

Stable Identifier

R-DRE-448423-2

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

IL10RB, A0FJI1

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-10 signaling (Danio rerio)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)
        
        IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
    - Interleukin-20 family signaling (Danio rerio)
      - IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
      - IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
      - IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
        
        IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
      - p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB6 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A0FJI1

Gene Names

CRFB6

Reference Genes

BioGPS Gene:562820 CRFB6

ENSEMBL:ENSDARG00000067795

KEGG Gene (Danio rerio):562820 CRFB6

Monarch:562820 CRFB6

NCBI Gene:562820 CRFB6

Reference Transcript

RefSeq:NM_001077627.1 CRFB6

Participates

as a member of

Homologues of IL10RB [plasma membrane] (Danio rerio)

Other forms of this molecule

CRFB6 [extracellular region]

CRFB6 [plasma membrane]

phospho-CRFB6 [plasma membrane]

CRFB6 [plasma membrane]

Inferred From

IL10RB [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001071095.1

ZFIN

ZDB-GENE-030131-5999