Reactome | cdc42 [plasma membrane]

cdc42 [plasma membrane]

Stable Identifier

R-DRE-449545

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

CDC42, Q52WY2

Locations in the PathwayBrowser

Expand all

Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - EPH-Ephrin signaling (Danio rerio)
      - EPHB-mediated forward signaling (Danio rerio)
        
        CDC42 and PIP2 bind WASL, activating it (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        N-WASP binds ARP2/3 and G-actin (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
    - Netrin-1 signaling (Danio rerio)
      - DCC mediated attractive signaling (Danio rerio)
        
        Activation of Cdc42 (Danio rerio)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        Recruitment and activation of N-WASP by Cdc42 (Danio rerio)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Danio rerio)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Costimulation by the CD28 family (Danio rerio)
    - CD28 co-stimulation (Danio rerio)
      - CD28 dependent Vav1 pathway (Danio rerio)
        
        Activation of PAKs by RAC1 and CDC42 (Danio rerio)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP, RAC1:GTP [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
    - Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
      - Detachment of WASP/WAVE (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        CDC42:GTP [plasma membrane] (Danio rerio)
        
        cdc42 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q52WY2

Gene Names

cdc42

Reference Genes

BioGPS Gene:336839 cdc42

ENSEMBL:ENSDARG00000044573

ENSEMBL:ENSDARG00000044573.8 cdc42

KEGG Gene (Danio rerio):336839 cdc42

Monarch:336839 cdc42

NCBI Gene:336839 cdc42

Reference Transcript

RefSeq:NM_001018120.2 cdc42

Other Identifiers

12976146

336839

A_15_P169911

CJ006315

CJ006317

CJ006410

CJ006412

CJ006612

CJ006613

CJ006615

CJ007021

CJ007023

CJ007245

CJ007247

DRER06706

DRER52093

Dr.26344.2.S1_a_at

Dr.26344.3.S1_a_at

ENSDART00000053432

ENSDART00000053432_x_1

ENSDART00000053432_x_2

ENSDART00000061944_x_1

ENSDART00000102800_x_1

GT_Spec_NM_001018120.2_44041

JP006713

JP006715

JP006808

JP006810

JP007010

JP007011

JP007013

JP007419

JP007421

JP007643

JP007645

NM_001018120

ZV700S00004755

ZV700S00004756

Participates

as a candidate of

as a component of

Other forms of this molecule

cdc42 [endoplasmic reticulum membrane]

cdc42 [cytosol]

Inferred From

CDC42 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001018130.1

ZFIN

ZDB-GENE-030131-8783

Ensembl

ENSDARP00000155235, ENSDARP00000129719, ENSDART00000189685, ENSDART00000154158, ENSDARG00000044573

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