Reactome | HERC2-SUMO1 [nucleoplasm]

HERC2-SUMO1 [nucleoplasm]

Stable Identifier

R-DRE-4551761

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

Q7SZR5

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - G2/M Checkpoints (Danio rerio)
    - G2/M DNA damage checkpoint (Danio rerio)
      - CHEK2 is recruited to DNA DSBs (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - Phosphorylation and activation of CHEK2 by ATM (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)

DNA Repair (Danio rerio)

- DNA Double-Strand Break Repair (Danio rerio)
  - DNA Double Strand Break Response (Danio rerio)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Danio rerio)
      - ATM phosphorylates TP53BP1 at DNA DSBs (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - CHEK2 is recruited to DNA DSBs (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - CHEK2 phosphorylates BRCA1 (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - PPP5C dephosphorylates TP53BP1 (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - Phosphorylation and activation of CHEK2 by ATM (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - RNF168 binds DNA DSBs (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - RNF8 and RNF168 ubiquitinate H2AFX (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - TP53BP1 associates with H4K20Me2 at DNA DSBs (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - UIMC1 and FAM175A bind DNA DSBs (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
  - Nonhomologous End-Joining (NHEJ) (Danio rerio)
    - Activated ATM phosphorylates DCLRE1C (Danio rerio)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
    - Association of Ku heterodimer with ends of DNA double-strand break (Danio rerio)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
    - TP53BP1 recruits DCLRE1C to ATM (Danio rerio)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Danio rerio)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Danio rerio)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Danio rerio)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        SUMO1:p-T4827-HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - SUMOylation (Danio rerio)
    - SUMO E3 ligases SUMOylate target proteins (Danio rerio)
      - SUMOylation of DNA damage response and repair proteins (Danio rerio)
        
        PIAS4 SUMOylates HERC2 with SUMO1 (Danio rerio)
        
        SUMO1:HERC2 [nucleoplasm] (Danio rerio)
        
        HERC2-SUMO1 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7SZR5

Reference Genes

BioGPS Gene:406438

dbSNP Gene:406438

ENSEMBL:ENSDARG00000044267

KEGG Gene (Danio rerio):406438

Monarch:406438

NCBI Gene:406438

Reference Transcript

RefSeq:NM_213159.1

Other Identifiers

1071785

13218465

406438

A_15_P103388

A_15_P168723

A_15_P185381

AAH56283

AAH67553

BC056283

BC067553

CJ014168

CJ014184

CJ014366

CJ014376

CUST_2266_PI428451958

Dr.5426.1.A1_at

DRER09165

ENSDARG00000044267

ENSDARP00000064994

ENSDART00000064995

ENSDART00000064995_y_2

ENSDART00000081149_x_1

ENSDART00000081149_x_2

ENSDART00000081205

EntrezGene:406438

EntrezGene:sumo1

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005886

GO:0006464

GO:0006950

GO:0008150

GO:0009790

GO:0016020

GO:0016605

GO:0016925

GO:0019899

GO:0031386

GO:0032991

GO:0034605

GO:0043009

GO:0043226

GO:0044389

GO:0048856

GO:0060216

GO:0071276

GO:0097165

GT_Spec_NM_213159.1_220655

IPR000626

IPR022617

IPR029071

IPR033950

MADDr01008814

NM_213159

NP_998324

OTTDART00000024414

PF11976

SM00213

sumo1

sumo1-201

UPI00001B97FF

ZDB-GENE-040426-2186

Participant Of

hasComponent

Other forms of this molecule

K14-UBE2I-G97-SUMO1 [nucleoplasm]

TOPORS-G97-SUMO1 [nucleoplasm]

PIAS4-G97-SUMO1 [nucleoplasm]

K2592-RANBP2-G97-SUMO1 [nuclear envelope]

K159-VHL-G97-SUMO1 [nucleoplasm]

MDM-G97-SUMO1 [nucleoplasm]

K554-TRIM28-G97-SUMO1 [nucleoplasm]

ING2-G97-SUMO1 [nucleoplasm]

NPM1-G97-SUMO1 [nucleoplasm]

DDX17-G97-SUMO1 [nucleoplasm]

PARK7-G97-SUMO1 [nucleoplasm]

K1154-NRIP1-G97-SUMO1 [nucleoplasm]

DDX5-G97-SUMO1 [nucleoplasm]

CASP8AP2-G97-SUMO1 [nucleoplasm]

K1020-EP300-G97-SUMO1 [nucleoplasm]

CTBP1-G97-SUMO1 [nucleoplasm]

K231-SAFB-G97-SUMO1 [nucleoplasm]

K499-MKL1-G97-SUMO1 [nucleoplasm]

K630-DAXX-G97-SUMO1 [nucleoplasm]

SIN3A-G97-SUMO1 [nucleoplasm]

HIPK2-G97-SUMO1 [nucleoplasm]

K732-NCOA1-G97-SUMO1 [nucleoplasm]

K499-MBD1-G97-SUMO1 [nucleoplasm]

ZNF131-G97-SUMO1 [nucleoplasm]

K298-NFKB2-G97-SUMO1 [cytosol]

UBE2I-G97-SUMO1 [cytosol]

p-S172-IKBKE-G97-SUMO1 [nucleoplasm]

K277-IKBKG-G97-SUMO1 [nucleoplasm]

NFKBIA-G97-SUMO1 [nucleoplasm]

RANGAP1-G97-SUMO1 [nucleoplasm]

TOP2B-G97-SUMO1 [nucleoplasm]

TOP1-G97-SUMO1 [nucleoplasm]

TOP2A-G97-SUMO1 [nucleoplasm]

K-PCNA-G97-SUMO1 [nucleoplasm]

MDC1-G97-SUMO1 [nucleoplasm]

STAG2-G97-SUMO1 [nucleoplasm]

RAD21-G97-SUMO1 [nucleoplasm]

K411-RAD52-G97-SUMO1 [nucleoplasm]

XRCC4-G97-SUMO1 [nucleoplasm]

K203-PARP1-G97-SUMO1 [nucleoplasm]

K356-WRN-G97-SUMO1 [nucleoplasm]

RNF168-SUMO1 [nucleoplasm]

XPC-G97-SUMO1 [nucleoplasm]

TDG-G97-SUMO1 [nucleoplasm]

SP100-G97-SUMO1 [nucleoplasm]

RXRA-G97-SUMO1 [nucleoplasm]

NR5A2-G97-SUMO1 [nucleoplasm]

K386-AR-G97-SUMO1 [nucleoplasm]

K277-NR3C1-G97-SUMO1 [nucleoplasm]

K283-THRA-G97-SUMO1 [nucleoplasm]

K399-NR3C2-G97-SUMO1 [nucleoplasm]

K119-NR5A1-G97-SUMO1 [nucleoplasm]

K266-ESR1-G97-SUMO1 [nucleoplasm]

K388-PGR-G97-SUMO1 [nucleoplasm]

NR1H4-G97-SUMO1 [nucleoplasm]

PPARA-G97-SUMO1 [nucleoplasm]

K146-THRB-G97-SUMO1 [nucleoplasm]

RORA-G97-SUMO1 [nucleoplasm]

HIC1-G97-SUMO1 [nucleoplasm]

TP53BP1-G97-SUMO1 [nucleoplasm]

SP3-G97-SUMO1 [nucleoplasm]

UBE2I-G97-SUMO1 [nucleoplasm]

UBA2-G97-SUMO1 [nucleoplasm]

SUMO1 [nucleoplasm]

SUMO1(2-101) [nucleoplasm]

TFAP2C-G97-SUMO1 [nucleoplasm]

BMI1-G97-SUMO1 [nucleoplasm]

K1971-CHD3-G97-SUMO1 [nucleoplasm]

HDAC4-G97-SUMO1 [nucleoplasm]

SATB1-G97-SUMO1 [nucleoplasm]

SUZ12-G97-SUMO1 [nucleoplasm]

CBX4-G97-SUMO1 [nucleoplasm]

K444-HDAC1-G97-SUMO1 [nucleoplasm]

DNMT1-G97-SUMO1 [nucleoplasm]

DNMT3B-G97-SUMO1 [nucleoplasm]

K467-NOP58-G97-SUMO1 [nucleoplasm]

HNRNPC-G97-SUMO1 [nucleoplasm]

K114-FOXL2-G97-SUMO1 [nucleoplasm]

K289-MITF-G97-SUMO1 [nucleoplasm]

Inferred From

HERC2-SUMO1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at 97 and unknown (in Homo sapiens)

Coordinate

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_998324.1

PRO

Q7SZR5