Reactome | mcfd2 [endoplasmic reticulum membrane]

mcfd2 [endoplasmic reticulum membrane]

Stable Identifier

R-DRE-5689470

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

endoplasmic reticulum membrane

Synonyms

MCFD2, Q5XJ39

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Asparagine N-linked glycosylation (Danio rerio)
    - Transport to the Golgi and subsequent modification (Danio rerio)
      - ER to Golgi Anterograde Transport (Danio rerio)
        
        COPII-mediated vesicle transport (Danio rerio)
        
        Inner coat assembly and cargo binding (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        Loss of SAR1B GTPase (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        SEC31:SEC13 and v-SNARE recruitment (Danio rerio)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        Cargo concentration in the ER (Danio rerio)
        
        Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        Inner coat assembly and cargo binding (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - ER to Golgi Anterograde Transport (Danio rerio)
    - COPII-mediated vesicle transport (Danio rerio)
      - Inner coat assembly and cargo binding (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
      - Loss of SAR1B GTPase (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
      - SEC31:SEC13 and v-SNARE recruitment (Danio rerio)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
    - Cargo concentration in the ER (Danio rerio)
      - Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
      - Inner coat assembly and cargo binding (Danio rerio)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Danio rerio)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Danio rerio)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Danio rerio)
        
        mcfd2 [endoplasmic reticulum membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5XJ39

Gene Names

mcfd2

Reference Genes

BioGPS Gene:449676 mcfd2

ENSEMBL:ENSDARG00000039757

ENSEMBL:ENSDARG00000109631 mcfd2

ENSEMBL:ENSDARG00000116502 mcfd2

KEGG Gene (Danio rerio):449676 mcfd2

Monarch:449676 mcfd2

NCBI Gene:449676 mcfd2

Reference Transcript

RefSeq:NM_001005939.1 mcfd2

Other Identifiers

13001493

449676

A_15_P142136

A_15_P569978

A_15_P661886

A_15_P664786

A_15_P666506

BC083471.1

BC095050

CUST_4529_PI428451958

DRER07649

Dr.26544.1.A1_at

Dr.4897.1.S1_at

ENSDART00000058107

ENSDART00000058107_1

ENSDART00000058107_2

GO:0003674

GO:0005509

GO:0005575

GO:0043167

GT_Spec_NM_001005939.1_471

MADDr01010033

OTTDART00000025956

Participant Of

hasComponent

hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane]

Other forms of this molecule

mcfd2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

mcfd2 [ER to Golgi transport vesicle membrane]

Inferred From

MCFD2 [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

RefSeq

NP_001005939.1

Ensembl

ENSDART00000187349, ENSDARP00000058105, ENSDARP00000157334, ENSDART00000182883, ENSDARG00000116502, ENSDART00000058107, ENSDART00000058106, ENSDARP00000058106, ENSDARG00000109631, ENSDARG00000039757, ENSDARP00000148496

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