Reactome | zgc:73211 [cytosol]

zgc:73211 [cytosol]

Stable Identifier

R-DRE-72343

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS19, Q6PBW7

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:73211 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PBW7

Gene Names

zgc:73211

Reference Genes

BioGPS Gene:393723 zgc:73211

ENSEMBL:ENSDARG00000030602

ENSEMBL:ENSDARG00000030602.9 zgc:73211

KEGG Gene (Danio rerio):393723 zgc:73211

Monarch:393723 zgc:73211

NCBI Gene:393723 zgc:73211

Reference Transcript

RefSeq:NM_200750.1 zgc:73211

Other Identifiers

13038556

393723

A_15_P194716

A_15_P467465

A_15_P750381

DRER05909

DRER35488

DRER56942

Dr.15372.2.S1_at

ENSDART00000048599

ENSDART00000048599_1

ENSDART00000048599_2

GO:0000028

GO:0002376

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0012501

GO:0022627

GO:0023052

GO:0030154

GO:0030218

GO:0035284

GO:0042254

GO:0042541

GO:0043009

GO:0043226

GO:0045088

GO:0045646

GO:0048821

GO:0048856

GO:0065003

GO:0072332

GO:0098542

GO:1990904

GT_Spec_NM_200750.1_150946

GT_Xhyb_XM_005158094.1_189725

LOLS10316

MADDr01008646

NM_200750

OTTDART00000028534

XM_697258

Participates

as a component of

40S ribosomal complex [cytosol] (Danio rerio)

Other forms of this molecule

zgc:73211 [nucleoplasm]

Inferred From

RPS19 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_957044.1

ZFIN

ZDB-GENE-040426-1716

Ensembl

ENSDARP00000048598, ENSDART00000048599, ENSDARG00000030602, ENSDART00000181520, ENSDARP00000152819

PDB

7OYA

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