Reactome | zgc:73262 [cytosol]

zgc:73262 [cytosol]

Stable Identifier

R-DRE-72361

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS27, Q6PBT1

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Translation (Danio rerio)
  - Eukaryotic Translation Initiation (Danio rerio)
    - Cap-dependent Translation Initiation (Danio rerio)
      - Formation of a pool of free 40S subunits (Danio rerio)
        
        Release of 40S and 60S subunits from the 80S ribosome (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
        
        eIF3 and eIF1A bind to the 40S subunit (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
        
        40S:eIF3:eIF1A [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
      - Formation of the ternary complex, and subsequently, the 43S complex (Danio rerio)
        
        Formation of the 43S pre-initiation complex (Danio rerio)
        
        40S:eIF3:eIF1A [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
        
        43S complex [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
      - Ribosomal scanning and start codon recognition (Danio rerio)
        
        Ribosomal scanning (Danio rerio)
        
        48S complex [cytosol] (Danio rerio)
        
        43S complex [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
        
        Start codon recognition (Danio rerio)
        
        48S complex [cytosol] (Danio rerio)
        
        43S complex [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Danio rerio)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Danio rerio)
        
        43S complex [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Danio rerio)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Danio rerio)
        
        43S complex [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
  - SRP-dependent cotranslational protein targeting to membrane (Danio rerio)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)
      - SRP:polypeptide+signal:ribosome [cytosol] (Danio rerio)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        RPS27,RPS27L [cytosol] (Danio rerio)
        
        zgc:73262 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PBT1

Gene Names

zgc:73262

Reference Genes

BioGPS Gene:393738 zgc:73262

CTD Gene:393738 zgc:73262

ENSEMBL:ENSDARG00000055475

ENSEMBL:ENSDARG00000055475.6 zgc:73262

KEGG Gene (Danio rerio):393738 zgc:73262

Monarch:393738 zgc:73262

NCBI Gene:393738 zgc:73262

Reference Transcript

RefSeq:NM_200765.1 zgc:73262

Other Identifiers

13038497

393738

A_15_P109273

BC059595.1

CUST_15495_PI428451953

CUST_98_PI428451961

DRER10945

DRER34024

DRER38863

Dr.14110.1.A1_at

ENSDART00000077834

ENSDART00000077834_1

ENSDART00000077834_2

GO:0000028

GO:0003723

GO:0003735

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0022627

GO:0042254

GO:0043226

GO:0046872

GO:0065003

GO:1990904

LOLS09595

MADDr01008657

NM_200765

OTTDART00000028530

Participates

as a member of

RPS27,RPS27L [cytosol] (Danio rerio)

Other forms of this molecule

zgc:73262 [nucleoplasm]

Inferred From

RPS27 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_957059.1

ZFIN

ZDB-GENE-040426-1735

Ensembl

ENSDARG00000055475, ENSDART00000077834, ENSDARP00000072300

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