Reactome | zgc:65996 [cytosol]

zgc:65996 [cytosol]

Stable Identifier

R-DRE-72418

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL17, Q7T1K0

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65996 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7T1K0

Gene Names

zgc:65996

Reference Genes

BioGPS Gene:336641 zgc:65996

ENSEMBL:ENSDARG00000057556

ENSEMBL:ENSDARG00000057556.5 zgc:65996

KEGG Gene (Danio rerio):336641 zgc:65996

Monarch:336641 zgc:65996

NCBI Gene:336641 zgc:65996

Reference Transcript

Other Identifiers

12930789

12937609

13109334

336641

A_15_P109695

CUST_8218_PI428451953

CUST_8219_PI428451953

CUST_8220_PI428451953

DRER11653

DRER31106

DRER32489

DRER34153

DRER43975

Dr.1351.1.S1_at

ENSDART00000080249

ENSDART00000080249_1

ENSDART00000080249_2

GO:0002181

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0022625

GO:0043226

GO:1990904

GT_Xhyb_NM_212760.1_215055

GT_Xhyb_XM_005161153.1_361715

MADDr01003638

NM_212760

XM_680042

ZV700S00001034

Participates

as a component of

Inferred From

RPL17 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001229966.1, NP_001306579.1

ZFIN

ZDB-GENE-030131-8585

Ensembl

ENSDARG00000057556, ENSDARP00000145162, ENSDARP00000122841, ENSDART00000132882, ENSDART00000187931, ENSDARP00000119756, ENSDART00000134746, ENSDARP00000113553, ENSDART00000131366

PDB

7OYB, 7OYA

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