Reactome | zgc:136952 [cytosol]

zgc:136952 [cytosol]

Stable Identifier

R-DRE-72456

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL32, Q24JV1

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:136952 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q24JV1

Gene Names

zgc:136952

Reference Genes

BioGPS Gene:556556 zgc:136952

ENSEMBL:ENSDARG00000054818

ENSEMBL:ENSDARG00000054818.5 zgc:136952

ENSEMBL:ENSDARG00000110237.1 zgc:136952

ENSEMBL:ENSDARG00000115707.1 zgc:136952

KEGG Gene (Danio rerio):556556 zgc:136952

Monarch:556556 zgc:136952

NCBI Gene:556556 zgc:136952

Reference Transcript

RefSeq:NM_001040043.2 zgc:136952

Other Identifiers

13123919

556556

A_15_P108047

A_15_P139241

DRER08068

Dr.5545.1.S1_at

ENSDART00000060005

ENSDART00000060005_1

ENSDART00000060005_2

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0043226

GO:1990904

GT_Spec_NM_001040043.2_87711

MADDr01003415

NM_001040043

OTTDART00000012488

XM_679383

Participates

as a component of

Inferred From

RPL32 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001035132.1

ZFIN

ZDB-GENE-060331-105

Ensembl

ENSDARG00000054818, ENSDARG00000115707, ENSDART00000191093, ENSDART00000181594, ENSDART00000060005, ENSDARP00000154755, ENSDARP00000150269, ENSDARP00000060004, ENSDARG00000110237

PDB

7OYB, 7OYA