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What is Reactome ?
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Digital Preservation
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Homologues of GRB2-1 [cytosol]
Stable Identifier
R-DRE-74686-3
Type
Set [DefinedSet]
Species
Danio rerio
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
Tie2 Signaling (Danio rerio)
Interaction of SOS-1 to Tie2 bound Grb2 (Danio rerio)
Grb2 bound to Tie2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
Grb2 bound to Tie2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Interaction of Tie2 and Grb2 (Danio rerio)
Grb2 bound to Tie2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
Grb2 bound to Tie2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Detachment of WASP/WAVE (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
GRB2:GAB1:PIK3R1 [cytosol] (Danio rerio)
GRB2:GAB1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
GRB2:GAB1:PIK3R1 [cytosol] (Danio rerio)
GRB2:GAB1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
Grb2 bound to Tie2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
Gastrin-CREB signalling pathway via PKC and MAPK (Danio rerio)
EGFR Transactivation by Gastrin (Danio rerio)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
EGFR downregulation (Danio rerio)
CBL binds to GRB2 (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Localization of CBL:GRB2 to the membrane (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2 events in EGFR signaling (Danio rerio)
GRB2-1 binds SOS1 (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1 complex binds to EGF:EGFR complex (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SHC1 events in EGFR signaling (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by ERBB2 (Danio rerio)
GRB2 events in ERBB2 signaling (Danio rerio)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by ERBB4 (Danio rerio)
SHC1 events in ERBB4 signaling (Danio rerio)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
FRS-mediated FGFR1 signaling (Danio rerio)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
GRB2:GAB1:PIK3R1 [cytosol] (Danio rerio)
GRB2:GAB1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SHC-mediated cascade:FGFR1 (Danio rerio)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Negative regulation of FGFR1 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
SPRY2 binds GRB2 (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
FRS-mediated FGFR2 signaling (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR2:pFRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SHC-mediated cascade:FGFR2 (Danio rerio)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Negative regulation of FGFR2 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
SPRY2 binds GRB2 (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
FRS-mediated FGFR3 signaling (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR3:pFRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SHC-mediated cascade:FGFR3 (Danio rerio)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Negative regulation of FGFR3 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
SPRY2 binds GRB2 (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
FRS-mediated FGFR4 signaling (Danio rerio)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Negative regulation of FGFR4 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
SPRY2 binds GRB2 (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
GRB2-1 binds SOS1 (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by MET (Danio rerio)
MET activates RAS signaling (Danio rerio)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Negative regulation of MET activity (Danio rerio)
CBL monoubiquitinates activated MET (Danio rerio)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Danio rerio)
p-Y-CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Danio rerio)
p-Y-CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
MET phosphorylates CBL (Danio rerio)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Danio rerio)
p-Y-CBL:GRB2 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
GRB2:SOS1 complex binds to the active receptor (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Activation of RAS by p-KIT bound SOS1 (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS interacts with p-KIT (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Regulation of KIT signaling (Danio rerio)
Recruitment of CBL to KIT (Danio rerio)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate WASPs and WAVEs (Danio rerio)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Detachment of WASP/WAVE (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Mother filament:branching complex [cytosol] (Danio rerio)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
RHO GTPase cycle (Danio rerio)
RHOU GTPase cycle (Danio rerio)
RHOU binds effectors at the plasma membrane (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
RHOU:GTP:RHOU effectors [plasma membrane] (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
Homologues of GRB2-1 [cytosol] (Danio rerio)
Participants
members
grb2a [cytosol]
(Danio rerio)
grb2b [cytosol]
(Danio rerio)
Participates
as a member of
RHOU effectors [cytosol] (Danio rerio)
SH3 domain proteins [cytosol] (Danio rerio)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p-Y-CBL:GRB2 [cytosol] (Danio rerio)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Danio rerio)
p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Danio rerio)
Grb2 bound to Tie2 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
GRB2:GAB1 [cytosol] (Danio rerio)
as an input of
GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
SPRY2 binds GRB2 (Danio rerio)
CBL binds to GRB2 (Danio rerio)
Interaction of Tie2 and Grb2 (Danio rerio)
GRB2-1 binds SOS1 (Danio rerio)
Inferred From
GRB2-1 [cytosol]
(Homo sapiens)
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