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pik3r2 [cytosol]
Stable Identifier
R-DRE-74791
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
PIK3R2, B3DHG9
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
Tie2 Signaling (Danio rerio)
Interaction of Tie2 and p85 of PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
p85 bound to Tie2 [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PIK3C(1) [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PIK3CB:PIK3R2 [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PIK3CD:PIK3R2 [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PIK3CB:PIK3R2 [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PIK3CD:PIK3R2 [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC1,RAC2,RHOG activate PI3K (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS:GTP binds PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
p21 RAS:GTP:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
G alpha (q) inhibits PI3K alpha (Danio rerio)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
PI3K binds membrane-associated estrogen receptors (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
Active ALK recruits PI3K (Danio rerio)
Active ALK:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
Active ALK:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by LTK (Danio rerio)
Active LTK receptor binds PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3-kinase binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Direct recruitment of PI3K to p-KIT (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-regulatory subunit [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase cycle (Danio rerio)
CDC42 GTPase cycle (Danio rerio)
CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)
CDC42 GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC1 GTPase cycle (Danio rerio)
RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)
RAC1 GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC2 GTPase cycle (Danio rerio)
RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)
RAC2 GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC2 binds effectors at the plasma membrane (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RAC3 GTPase cycle (Danio rerio)
RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)
RAC3 GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RHOA GTPase cycle (Danio rerio)
RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)
RHOA GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RHOD GTPase cycle (Danio rerio)
RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)
RHOD GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RHOF GTPase cycle (Danio rerio)
RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)
RHOF GAPs [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RHOU GTPase cycle (Danio rerio)
RHOU binds effectors at the plasma membrane (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RHOU:GTP:RHOU effectors [plasma membrane] (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RND1 GTPase cycle (Danio rerio)
RND1 binds effectors (Danio rerio)
RND1 effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RND1:GTP:RND1 effectors [plasma membrane] (Danio rerio)
RND1 effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RND2 GTPase cycle (Danio rerio)
RND2 binds effectors (Danio rerio)
RND2 effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RND2:GTP:RND2 effectors [plasma membrane] (Danio rerio)
RND2 effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RND3 GTPase cycle (Danio rerio)
RND3 binds effectors (Danio rerio)
RND3 effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
RND3:GTP:RND3 effectors [plasma membrane] (Danio rerio)
RND3 effectors [cytosol] (Danio rerio)
pik3r2 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:B3DHG9
Gene Names
pik3r2
Reference Genes
BioGPS Gene:404211 pik3r2
ENSEMBL:ENSDARG00000018060
ENSEMBL:ENSDARG00000018060.12 pik3r2
KEGG Gene (Danio rerio):404211 pik3r2
Monarch:404211 pik3r2
NCBI Gene:404211 pik3r2
Reference Transcript
RefSeq:XM_005163370.4 pik3r2
RefSeq:NM_212822.2 pik3r2
RefSeq:XM_005163369.4 pik3r2
Other Identifiers
13081143
404211
A_15_P119949
A_15_P450510
CUST_18370_PI428451953
CUST_4483_PI428451958
DRER07386
ENSDART00000056822
ENSDART00000056822_2
GO:0005942
GO:0006629
GO:0007165
GO:0008286
GO:0023052
GO:0030154
GO:0046854
GO:0046935
GO:0048468
GO:0048731
GO:0048856
GO:0098772
GT_Xhyb_NM_212822.1_122516
JP011512
JP011523
JP011528
LOLO1545
LOLS04831
MADDr01008327
NM_212822
OTTDART00000024358
Participates
as a candidate of
RND2 effectors [cytosol] (Danio rerio)
RHOA GAPs [cytosol] (Danio rerio)
RND3 effectors [cytosol] (Danio rerio)
CDC42 GAPs [cytosol] (Danio rerio)
RAC2 GAPs [cytosol] (Danio rerio)
RHOD GAPs [cytosol] (Danio rerio)
RAC1 GAPs [cytosol] (Danio rerio)
RHOF GAPs [cytosol] (Danio rerio)
RAC3 GAPs [cytosol] (Danio rerio)
RHOU effectors [cytosol] (Danio rerio)
RND1 effectors [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
as a component of
PIK3CB:PIK3R2 [cytosol] (Danio rerio)
PIK3CD:PIK3R2 [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
as a member of
PI3K-regulatory subunit [cytosol] (Danio rerio)
Other forms of this molecule
pik3r2 [cytosol]
Inferred From
PIK3R2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_997987.2
,
XP_005163426.1
,
XP_005163427.1
ZFIN
ZDB-GENE-040309-1
Ensembl
ENSDART00000170467
,
ENSDARG00000018060
,
ENSDARP00000130009
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