Reactome | dab2 [cytosol]

dab2 [cytosol]

Stable Identifier

R-DRE-8862456

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

DAB2, B8A566

Locations in the PathwayBrowser

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Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
      - CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
      - DAB2 binds LRP2 (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - LDLR is bound by DAB2 and ARH (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Clathrin recruits PIK3C2A (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Danio rerio)
        
        DAB2,LDLRAP1 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)
        
        LRP2:DAB2 [plasma membrane] (Danio rerio)
        
        dab2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:B8A566

Gene Names

dab2

Reference Genes

BioGPS Gene:404040 dab2

ENSEMBL:ENSDARG00000031761

KEGG Gene (Danio rerio):404040 dab2

Monarch:404040 dab2

NCBI Gene:404040 dab2

Reference Transcript

Other Identifiers

13205578

404040

A_15_P101828

A_15_P105106

A_15_P519727

A_15_P652756

BC065585

CUST_25715_PI428451953

CUST_25716_PI428451953

CUST_25717_PI428451953

CUST_25718_PI428451953

CUST_25719_PI428451953

CUST_6061_PI428451958

DRER02215

DRER03901

DRER05807

DRER12597

DRER38657

Dr.9443.1.A1_at

ENSDART00000017956

ENSDART00000017956_1

ENSDART00000017956_2

ENSDART00000031120

ENSDART00000047670

GO:0001525

GO:0001944

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006898

GO:0007165

GO:0007219

GO:0007267

GO:0008150

GO:0009058

GO:0016192

GO:0030510

GO:0034641

GO:0045807

GO:0048646

GO:0048856

GO:0090090

GT_Xhyb_XM_005171819.1_322585

GT_Xhyb_XM_005171820.1_322595

GT_Xhyb_XM_005171821.1_384865

GT_Xhyb_XM_005171822.1_384875

LOLS05628

MADDr01008323

NM_205757

OTTDART00000030408

OTTDART00000030409

OTTDART00000030410

Participant Of

hasMember

hasComponent

input

DAB2 binds LRP2

Other forms of this molecule

dab2 [lysosomal membrane]

dab2 [plasma membrane]

Inferred From

DAB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005171876.1, NP_001314800.1

Ensembl

ENSDARG00000031761, ENSDART00000047670, ENSDARP00000047669

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