Reactome | btbd6b [cytosol]

btbd6b [cytosol]

Stable Identifier

R-DRE-8863208

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

BTBD6, Q5TZE1

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        btbd6b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5TZE1

Gene Names

btbd6b

Reference Genes

BioGPS Gene:553533 btbd6b

CTD Gene:553533 btbd6b

ENSEMBL:ENSDARG00000032369

KEGG Gene (Danio rerio):553533 btbd6b

Monarch:553533 btbd6b

NCBI Gene:553533 btbd6b

Reference Transcript

RefSeq:NM_001024815.2 btbd6b

Other Identifiers

13102124

553533

A_15_P118305

A_15_P143366

A_15_P225901

A_15_P726706

A_15_P732291

BC076137.1

BC124114

CUST_2249_PI424165564

CUST_2250_PI424165564

CUST_2251_PI424165564

CUST_2252_PI424165564

CUST_2253_PI424165564

CUST_2254_PI424165564

CUST_2255_PI424165564

CUST_2256_PI424165564

CUST_4727_PI428451958

DRER04782

DRER25527

DRER50376

DRER50675

DRER50704

Dr.20785.1.S1_a_at

Dr.25528.1.A1_at

ENSDART00000039907

ENSDART00000039907_1

ENSDART00000039907_2

GO:0005515

GT_Xhyb_NM_001024815.2_214645

GT_Xhyb_XM_005160494.1_387005

MADDr01014585

NM_001024815

OTTDART00000005309

XM_682124

Participates

as a member of

BTB proteins [cytosol] (Danio rerio)

Inferred From

BTBD6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001019986.1

ZFIN

ZDB-GENE-030829-65

Ensembl

ENSDARP00000153969, ENSDARG00000114044, ENSDARG00000032369, ENSDART00000039907, ENSDART00000192629, ENSDARP00000039906

PRO

Q5TZE1

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