Reactome | si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane]

si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DRE-8869082

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

CD4, A0A140LFN1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of CD4 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        si:ch73-296e2.3 [clathrin-coated endocytic vesicle membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A140LFN1

Gene Names

si:ch73-296e2.3

Reference Genes

ENSEMBL:ENSDARG00000079769

Other Identifiers

1083679

13036702

A_15_P270886

CU467865

DRER42393

ENSDARG00000079769

ENSDARP00000142054

ENSDART00000080571

ENSDART00000143845

GO:0002376

GO:0003674

GO:0005575

GO:0005623

GO:0005886

GO:0006464

GO:0007165

GO:0008150

GO:0009897

GO:0019899

GO:0035723

GO:0042110

GO:0042289

GO:0045121

GO:0070374

GO:1990782

IPR003598

IPR003599

IPR007110

IPR013783

IPR036179

PF13927

si:ch73-296e2.3

si:ch73-296e2.3-201

SM00408

SM00409

UPI000772115D

ZDB-GENE-100922-156

Participant Of

hasMember

Homologues of CD4 [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

si:ch73-296e2.3 [plasma membrane]

Inferred From

CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

Ensembl

ENSDART00000143845, ENSDARP00000142054, ENSDARG00000079769