Reactome | TFRC(1-760) [clathrin-coated endocytic vesicle membrane]

TFRC(1-760) [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DRE-8869124

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Q5MPX4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5MPX4

Reference Genes

BioGPS Gene:494477

CTD Gene:494477

dbSNP Gene:494477

ENSEMBL:ENSDARG00000101322

KEGG Gene (Danio rerio):494477

Monarch:494477

NCBI Gene:494477

Reference Transcript

Other Identifiers

1065210

13086214

13301116

494477

A_15_P172511

A_15_P623461

AAV66588

AY649363

BX663506

CJ007448

CJ007449

CJ007450

CU929154

CUST_8495_PI428451958

DRER12081

DRER38540

ENSDARG00000101322

ENSDARP00000137503

ENSDARP00000150808

ENSDART00000081717

ENSDART00000081717_2

ENSDART00000165296

ENSDART00000189835

EntrezGene:494477

EntrezGene:tfr1a

GO:0002376

GO:0003674

GO:0004998

GO:0005575

GO:0005623

GO:0005886

GO:0006810

GO:0006879

GO:0006898

GO:0008150

GO:0009058

GO:0009790

GO:0016020

GO:0016021

GO:0016192

GO:0022857

GO:0030154

GO:0030218

GO:0033570

GO:0033572

GO:0035162

GO:0042541

GO:0042592

GO:0048856

GT_Xhyb_NM_001009917.1_116226

IPR003137

IPR007365

IPR007484

IPR029513

IPR036757

IPR037324

IPR039373

JP007846

JP007847

JP007848

MADDr01010365

NM_001009917

NP_001009917

OTTDART00000023773

PF02225

PF04253

PF04389

tfr1a

tfr1a-201

tfr1a-202

UPI00004981FD

XM_005163666

XP_005163723

ZDB-GENE-041220-1

Participant Of

hasComponent

TFRC dimer [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

TFRC(1-760) [Golgi membrane]

TFRC(1-760) [cytoplasmic vesicle membrane]

TFRC(1-760) [plasma membrane]

TFRC(1-760) [endosome membrane]

Inferred From

TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_005163723.1, NP_001009917.1