Reactome | vamp2 [clathrin-coated endocytic vesicle membrane]

vamp2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DRE-8869129

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP2, Q7SZZ5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        vamp2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7SZZ5

Gene Names

vamp2

Reference Genes

BioGPS Gene:336281 vamp2

ENSEMBL:ENSDARG00000056877

KEGG Gene (Danio rerio):336281 vamp2

Monarch:336281 vamp2

NCBI Gene:336281 vamp2

Reference Transcript

RefSeq:NM_200005.1 vamp2

Other Identifiers

12968406

336281

A_15_P113253

A_15_P119559

A_15_P236271

DRER11455

ENSDART00000079454

ENSDART00000079454_1

ENSDART00000079454_2

GO:0003674

GO:0005484

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006906

GO:0008150

GO:0016020

GO:0016021

GO:0016192

GO:0017075

GO:0019905

GO:0022607

GO:0030674

GO:0031201

GO:0031982

GO:0032154

GO:0032991

GO:0035493

GO:0043226

GO:0061024

GO:0065003

GT_Spec_NM_200005.1_34681

LOLS14897

MADDr01004886

NM_200005

OTTDART00000002302

Participant Of

hasMember

VAMP2,3,8 [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

vamp2 [secretory granule membrane]

vamp2 [cytoplasmic vesicle membrane]

vamp2 [Golgi membrane]

vamp2 [lysosomal membrane]

vamp2 [cytosol]

vamp2 [clathrin-sculpted monoamine transport vesicle membrane]

vamp2 [clathrin-sculpted glutamate transport vesicle membrane]

vamp2 [plasma membrane]

vamp2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Inferred From

VAMP2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_956299.1

ZFIN

ZDB-GENE-030131-8225

Ensembl

ENSDART00000079454, ENSDARP00000073910, ENSDARG00000056877

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