Reactome | commd9 [cytosol]

commd9 [cytosol]

Stable Identifier

R-DRE-8955114

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

COMMD9, A4QN68

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - 26S proteasome degrades HIFalpha (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Danio rerio)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Danio rerio)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Danio rerio)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Danio rerio)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        COMMDs [cytosol] (Danio rerio)
        
        commd9 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A4QN68

Gene Names

commd9

Reference Genes

BioGPS Gene:562660 commd9

ENSEMBL:ENSDARG00000094258

KEGG:dre:562660 commd9

Monarch:562660 commd9

NCBI Gene:562660 commd9

UCSC:A4QN68 commd9

Reference Transcript

RefSeq:NM_001089398.1 commd9

Other Identifiers

13277702

13277712

13283074

13283392

13285804

562660

A_15_P120753

A_15_P153307

CUST_2349_PI428451953

DRER14215

DRER42121

DRER46160

ENSDART00000092925

ENSDART00000092925_1

ENSDART00000092925_2

MADDr01005487

NM_001044857

NM_001045326

OTTDART00000029459

XM_686034

Participates

as a candidate of

COMMDs [cytosol] (Danio rerio)

Other forms of this molecule

commd9 [nucleoplasm]

commd9 [secretory granule lumen]

commd9 [extracellular region]

commd9 [ficolin-1-rich granule lumen]

Inferred From

COMMD9 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001082867.1

ENSEMBL

ENSDART00000092925, ENSDARG00000094258, ENSDARP00000087357

ZFIN

ZDB-GENE-070424-139

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