Reactome | tfr1a [plasma membrane]

tfr1a [plasma membrane]

Stable Identifier

R-DRE-917983

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

TFRC(1-760), Q5MPX4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
      - CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
      - AP-2 directly binds some endocytic cargo (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - Clathrin recruits PIK3C2A (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        AP-2:cargo [plasma membrane] (Danio rerio)
        
        AP-2 cargo [plasma membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [plasma membrane] (Danio rerio)
        
        holoTF:TFRC dimer [plasma membrane] (Danio rerio)
        
        TFRC dimer [plasma membrane] (Danio rerio)
        
        tfr1a [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5MPX4

Gene Names

tfr1a

Reference Genes

BioGPS Gene:494477 tfr1a

CTD Gene:494477 tfr1a

ENSEMBL:ENSDARG00000101322

KEGG Gene (Danio rerio):494477 tfr1a

Monarch:494477 tfr1a

NCBI Gene:494477 tfr1a

Reference Transcript

Other Identifiers

13086214

13301116

494477

A_15_P172511

A_15_P623461

CJ007448

CJ007449

CJ007450

CUST_8495_PI428451958

DRER12081

DRER38540

ENSDART00000081717

ENSDART00000081717_2

GO:0002376

GO:0003674

GO:0004998

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006826

GO:0006879

GO:0006897

GO:0006898

GO:0008150

GO:0008233

GO:0008235

GO:0009058

GO:0009790

GO:0009897

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0030154

GO:0030218

GO:0031410

GO:0031623

GO:0033572

GO:0035162

GO:0042470

GO:0042541

GO:0042592

GO:0043226

GO:0048856

GO:0110165

GT_Xhyb_NM_001009917.1_116226

JP007846

JP007847

JP007848

MADDr01010365

NM_001009917

OTTDART00000023773

Participates

as a candidate of

as a component of

TFRC dimer [plasma membrane] (Danio rerio)

Other forms of this molecule

tfr1a [clathrin-coated endocytic vesicle membrane]

tfr1a [Golgi membrane]

tfr1a [cytoplasmic vesicle membrane]

tfr1a [endosome membrane]

Inferred From

TFRC(1-760) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005163723.1, NP_001009917.1

Ensembl

ENSDARP00000150808, ENSDARG00000101322, ENSDART00000189835, ENSDART00000165296, ENSDARP00000137503

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