Reactome | upf3a [cytosol]

upf3a [cytosol]

Stable Identifier

R-DRE-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

UPF3A, B0S733

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        UPF3 [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        UPF3 [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        UPF3 [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        UPF3 [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        UPF3 [cytosol] (Danio rerio)
        
        upf3a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:B0S733

Gene Names

upf3a

Reference Genes

BioGPS Gene:566608 upf3a

ENSEMBL:ENSDARG00000069297

KEGG Gene (Danio rerio):566608 upf3a

Monarch:566608 upf3a

NCBI Gene:566608 upf3a

Reference Transcript

Other Identifiers

13268354

566608

A_15_P201821

CUST_23189_PI428451953

CUST_23190_PI428451953

CUST_9470_PI428451958

DRER15476

DRER24844

DRER30018

DRER38546

ENSDART00000100728

ENSDART00000100728_2

GO:0000184

GO:0003676

GO:0016071

GT_Xhyb_NM_001202448.1_62491

MADDr01012578

XM_689824

XM_689884

Participates

as a component of

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)

as a member of

UPF3 [cytosol] (Danio rerio)

Inferred From

UPF3AS-2 [cytosol] (Homo sapiens)

UPF3A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001189377.1, XP_017213192.1, XP_005167908.1

ZFIN

ZDB-GENE-060721-2

Ensembl

ENSDARP00000114416, ENSDART00000100728, ENSDARG00000069297, ENSDARP00000105134, ENSDART00000139608, ENSDART00000123005, ENSDARG00000111067, ENSDARP00000091501

PRO

B0S733