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NS1 [cytosol]
Stable Identifier
R-FLU-169118
Type
Protein [EntityWithAccessionedSequence]
Species
Influenza A virus
Compartment
host cell cytosol
,
cytosol
GO Cellular Component
host cell cytosol
(0044164)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral mRNA Translation (Homo sapiens)
Viral Protein Synthesis (Homo sapiens)
NS1 [cytosol] (Influenza A virus)
Viral Proteins [endoplasmic reticulum membrane] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Inhibition of Interferon Synthesis (Homo sapiens)
Inhibition of IFN-beta (Homo sapiens)
Binding of NS1 to dsRNA (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1:viral dsRNA Complex [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Inhibition of PKR (Homo sapiens)
Binding of NS1 to PKR (Homo sapiens)
NS1 Homodimer:PKR Complex [cytosol] (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Binding of NS1 to dsRNA (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1:viral dsRNA Complex [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
ISGylated NS1 [cytosol] (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
ISGylation of viral protein NS1 (Homo sapiens)
ISGylated NS1 [cytosol] (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
ISGylated NS1 [cytosol] (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL oligomerizes (Homo sapiens)
NS1:MLKL [cytosol] (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
IAV NS1 binds MLKL (Homo sapiens)
NS1:MLKL [cytosol] (Homo sapiens)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
NS1 dimer [cytosol] (Influenza A virus)
NS1 [cytosol] (Influenza A virus)
External Reference Information
External Reference
UniProt:P03496 NS
Gene Names
NS
Chain
chain:1-230
Reference Genes
BioGPS Gene:956533 NS
KEGG Gene (Viruses):956533 NS
Monarch:956533 NS
NCBI Gene:956533 NS
Reference Transcript
RefSeq:NC_002020.1 NS
Participant Of
hasComponent
NS1 dimer [cytosol]
Viral Proteins [endoplasmic reticulum membrane]
This entity regulates
Positively
Viral Protein Synthesis
Other forms of this molecule
NS1 [nucleoplasm]
Cross References
RefSeq
NP_040984.1
PRO
P03496
PDB
3O9T
,
3L4Q
,
2GX9
,
3O9U
,
2ZKO
,
3O9S
,
5NT2
,
3O9R
,
3RVC
,
3O9Q
,
5NT1
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95793 STAU1
0.813
6
UniProt:O00459 PIK3R2
2
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
0.752
13
UniProt:P03496 NS
2
NS1 [cytosol]
(R-FLU-169118)
NS1 [nucleoplasm]
(R-FLU-169113)
0.74
4
UniProt:O75569 PRKRA
1
PRKRA [cytosol]
(R-HSA-2399897)
0.667
3
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.659
6
UniProt:P55265 ADAR
1
ADAR [nucleoplasm]
(R-HSA-53939)
0.655
8
UniProt:Q14258 TRIM25
2
TRIM25 [cytosol]
(R-HSA-918186)
TRIM25 [nucleoplasm]
(R-HSA-5653667)
0.556
3
UniProt:Q15633 TARBP2
1
TARBP2 [cytosol]
(R-HSA-203864)
0.553
2
UniProt:Q9NUL3 STAU2
0.547
2
UniProt:Q12906 ILF3
0.547
3
UniProt:P06733 ENO1
1
ENO1 [cytosol]
(R-HSA-71437)
0.547
2
UniProt:P42336 PIK3CA
25
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
PIK3CA R38H [cytosol]
(R-HSA-1500718)
PIK3CA R38S [cytosol]
(R-HSA-2395947)
PIK3CA R38G [cytosol]
(R-HSA-2395950)
PIK3CA R38C [cytosol]
(R-HSA-1500691)
PIK3CA [cytosol]
(R-HSA-74787)
0.527
7
UniProt:Q9HCE1 MOV10
1
MOV10 [cytosol]
(R-HSA-427772)
0.527
3
UniProt:Q02539 H1-1
1
HIST1H1A [nucleoplasm]
(R-HSA-211245)
0.527
3
UniProt:Q9Y3I0 RTCB
1
RTCB [nucleoplasm]
(R-HSA-5696792)
0.527
3
UniProt:Q9Y2I1 NISCH
0.527
6
UniProt:Q9NNW5 WDR6
0.527
6
UniProt:Q92900 UPF1
2
p-4S-UPF1 [cytosol]
(R-HSA-927856)
UPF1 [cytosol]
(R-HSA-927734)
0.527
2
UniProt:Q92569 PIK3R3
2
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
PIK3R3 [cytosol]
(R-HSA-205223)
0.527
6
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