Reactome | NS1 [cytosol]

NS1 [cytosol]

Stable Identifier

R-FLU-169118

Type

Protein [EntityWithAccessionedSequence]

Species

Influenza A virus

Compartment

host cell cytosol, cytosol

GO Cellular Component

host cell cytosol (0044164)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P03496 NS

Gene Names

Chain

chain:1-230

Reference Genes

BioGPS Gene:956533 NS

KEGG Gene (Viruses):956533 NS

Monarch:956533 NS

NCBI Gene:956533 NS

Reference Transcript

RefSeq:NC_002020.1 NS

Participant Of

hasComponent

This entity regulates

Positively

Viral Protein Synthesis

Other forms of this molecule

NS1 [nucleoplasm]

Cross References

RefSeq

NP_040984.1

PRO

P03496

PDB

5NT2, 2GX9, 3O9U, 3O9T, 3O9S, 2ZKO, 3O9R, 3RVC, 3L4Q, 5NT1, 3O9Q

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95793 STAU1			0.813	6
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.752	13
UniProt:P03496 NS	2	NS1 [cytosol] (R-FLU-169118) NS1 [nucleoplasm] (R-FLU-169113)	0.74	4
UniProt:O75569 PRKRA	1	PRKRA [cytosol] (R-HSA-2399897)	0.667	3
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.659	6
UniProt:P55265 ADAR	1	ADAR [nucleoplasm] (R-HSA-53939)	0.655	8
UniProt:Q14258 TRIM25	2	TRIM25 [cytosol] (R-HSA-918186) TRIM25 [nucleoplasm] (R-HSA-5653667)	0.556	3
UniProt:Q15633 TARBP2	1	TARBP2 [cytosol] (R-HSA-203864)	0.553	2
UniProt:Q9NUL3 STAU2			0.547	2
UniProt:Q12906 ILF3			0.547	3
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.547	2
UniProt:P42336 PIK3CA	25	PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA [cytosol] (R-HSA-74787)	0.527	7
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	3
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	3
UniProt:Q9Y3I0 RTCB	1	RTCB [nucleoplasm] (R-HSA-5696792)	0.527	3
UniProt:Q9Y2I1 NISCH			0.527	6
UniProt:Q9NNW5 WDR6			0.527	6
UniProt:Q92900 UPF1	2	p-4S-UPF1 [cytosol] (R-HSA-927856) UPF1 [cytosol] (R-HSA-927734)	0.527	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.527	6