Reactome | Activated TAK1 leaves endosome membrane

Activated TAK1 leaves endosome membrane

Stable Identifier

R-GGA-1008270

Type

Reaction [transition]

Species

Gallus gallus

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR21 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        Activated TAK1 leaves endosome membrane (Gallus gallus)
  - TLR7 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        Activated TAK1 leaves endosome membrane (Gallus gallus)

General

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It's believed that TAK1 dissociates from the membrane in to cytosol where it regulates NF-kB and MAPKs activation.

Literature References

PubMed ID	Title	Journal	Year
19898473	Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines Mino, T, Matsuzawa, A, Karin, M, Zhang, W, Tseng, PH, Vignali, DA	Nat Immunol	2010
12609980	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z, Nie, H, Li, X, Williams, BR, Zamanian-Daryoush, M, Silva, AM	J Biol Chem	2003