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phospho-p-S218,S222-MAP2K1 [cytosol]
Stable Identifier
R-GGA-109837
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Q5ZIF0
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF-independent MAPK1/3 activation (Gallus gallus)
MAPK3 (ERK1) activation (Gallus gallus)
Inactivation of MAP2K1 by CDK1 (Gallus gallus)
MAP2K1 [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
RAF activation (Gallus gallus)
Phosphorylation of RAF (Gallus gallus)
RAF activating kinases [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Signalling to ERKs (Gallus gallus)
Prolonged ERK activation events (Gallus gallus)
Frs2-mediated activation (Gallus gallus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
phospho-p-S218,S222-MAP2K1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q5ZIF0
Reference Genes
BioGPS Gene:415549
ENSEMBL:ENSGALG00000007687
KEGG Gene (Gallus gallus):415549
Monarch:415549
NCBI Gene:415549
Reference Transcript
RefSeq:NM_001005830.1
Participates
as a member of
MAP2K1 [cytosol] (Gallus gallus)
as a component of
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-p-T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
MAP2K1 [cytosol]
Inferred From
p-S218,S222-MAP2K1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001005830.1
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