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phospho-p-T185,Y187-MAPK1 [cytosol]
Stable Identifier
R-GGA-109853
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A3S5ZPA9
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Prophase (Gallus gallus)
Golgi Cisternae Pericentriolar Stack Reorganization (Gallus gallus)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)
p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to heat stress (Gallus gallus)
Regulation of HSF1-mediated heat shock response (Gallus gallus)
Constitutive phosphorylation by pERK1/2 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
MAPK-dependent phosphorylation of KARS (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
MAPK1-dependent phosphorylation of MITF-M (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
L1CAM interactions (Gallus gallus)
Recycling pathway of L1 (Gallus gallus)
Phosphorylation of L1 by ERK (Gallus gallus)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Gallus gallus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Gallus gallus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Thrombin signalling through proteinase activated receptors (PARs) (Gallus gallus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Growth hormone receptor signaling (Gallus gallus)
Lyn activates ERK (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon gamma signaling (Gallus gallus)
IFNG signaling activates MAPKs (Gallus gallus)
JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
p-ERK phosphorylates WAVEs and ABI (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Intrinsic Pathway for Apoptosis (Gallus gallus)
Apoptotic factor-mediated response (Gallus gallus)
Cytochrome c-mediated apoptotic response (Gallus gallus)
Formation of apoptosome (Gallus gallus)
Regulation of the apoptosome activity (Gallus gallus)
CASP9 is phosphorylated at T412 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF-independent MAPK1/3 activation (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
PEA15 binds MAPK monomers and dimers (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPKs dimerize (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Negative feedback regulation of MAPK pathway (Gallus gallus)
Activated MAPK phosphorylates RAF1 (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Activated MAPKs phosphorylate BRAF (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
PEA15 binds MAPK monomers and dimers (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Gallus gallus)
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPKs dimerize (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
PLC beta mediated events (Gallus gallus)
Ca-dependent events (Gallus gallus)
phospho-PLA2 pathway (Gallus gallus)
Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
Estrogen-stimulated signaling through PRKCZ (Gallus gallus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Negative regulation of FGFR1 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by FGFR2 (Gallus gallus)
Negative regulation of FGFR2 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by FGFR3 (Gallus gallus)
Negative regulation of FGFR3 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by FGFR4 (Gallus gallus)
Negative regulation of FGFR4 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Signalling to ERKs (Gallus gallus)
Prolonged ERK activation events (Gallus gallus)
Frs2-mediated activation (Gallus gallus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
p-T,Y MAPKs dimerize (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate NADPH Oxidases (Gallus gallus)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
RHO GTPases Activate WASPs and WAVEs (Gallus gallus)
p-ERK phosphorylates WAVEs and ABI (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
Signaling by TGFB family members (Gallus gallus)
Signaling by TGF-beta Receptor Complex (Gallus gallus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Gallus gallus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Gallus gallus)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
phospho-p-T185,Y187-MAPK1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3S5ZPA9
Reference Genes
ENSEMBL:ENSGALG00000001501
Participates
as an output of
Lyn activates ERK (Gallus gallus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
as a component of
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Gallus gallus)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Gallus gallus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol] (Gallus gallus)
as an input of
Phosphorylation of L1 by ERK (Gallus gallus)
p-T,Y MAPKs dimerize (Gallus gallus)
as a member of
p-T,Y MAPK monomers and dimers [cytosol] (Gallus gallus)
Other forms of this molecule
MAPK1 [azurophil granule lumen]
MAPK1 [extracellular region]
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [nucleoplasm]
MAPK1 [cytosol]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
p-T,Y MAPKs [cytosol]
(Homo sapiens)
p-T185,Y187-MAPK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
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