Chicken MDA5 shares 60% overall sequence identity with human MDA5. Detailed analysis of human and chicken MDA5 revealed considerable sequence divergence between N-terminal effector CARD domains (43% amino acid identity), while the C-terminal helicase domains showed a relatively high degree of conservation (67% amino acid identity with extended regions of over 80%) (Childs et al., 2007).
Webster, RG, Barber, MR, Magor, KE, Aldridge JR, Jr
Forlenza, M, Maier, HJ, Langereis, MA, Koumans, J, Fernandez-Gutierrez, M, Wiegertjes, GF, Britton, P, Kint, J
Goodbourn, S, Ross, C, Stock, N, Randall, RE, Childs, KS, Skinner, M, Andrejeva, J, Hilton, L
Zhang, Y, Li, S, Tien, P, Chen, D, Xu, LG, Zhang, M, Tian, Y, Diao, F, Shu, HB, Zhong, B, Zhai, Z, Wang, RP
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