Reactome: A Curated Pathway Database

NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding.

Stable Identifier
R-GGA-1227695
Type
Reaction
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
Locations in the PathwayBrowser
Summation

Predicted chicken NLRC5 shows 34% amino acid sequence identity to its human counterpart. Mammalian NLRC5 blocks the CARD-CARD interaction between IPS-1 and RIG-1/MDA5 by specific binding to the CARD domains of RIG-1/ MDA5.

Literature References
Participants
Participant Of
Inferred From