NLRX1 inhibits IPS1 signaling

Stable Identifier
R-GGA-1227698
Type
Reaction [binding]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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NLRX1 is a member of nucleotide-binding domain and leucine-rich repeat containing (NLR) protein family. Upon viral stimulation mammalian NLRX1 competes with RIG-I for IPS-1 interaction and has been identified as a negative regulator of RLR signaling.
Literature References
PubMed ID Title Journal Year
18200010 NLRX1 is a regulator of mitochondrial antiviral immunity

Ting, JP, Duncan, JA, Lei, Y, Heise, MT, Lich, JD, Sun, L, Chen, Z, Ye, Z, Zimmermann, AG, Bergstralh, DT, Accavitti-Loper, MA, Morrison, TE, Madden, VJ, Moore, CB

Nature 2008
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