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NLRX1 inhibits IPS1 signaling

Stable Identifier
R-GGA-1227698
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

NLRX1 is a member of nucleotide-binding domain and leucine-rich repeat containing (NLR) protein family. Upon viral stimulation mammalian NLRX1 competes with RIG-I for IPS-1 interaction and has been identified as a negative regulator of RLR signaling.

Literature References
PubMed ID Title Journal Year
18200010 NLRX1 is a regulator of mitochondrial antiviral immunity Nature 2008
Participants
Participant Of
Inferred From