NLRX1 inhibits IPS1 signaling

Stable Identifier
R-GGA-1227698
Type
Reaction
Species
Gallus gallus
Compartment
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Summation

NLRX1 is a member of nucleotide-binding domain and leucine-rich repeat containing (NLR) protein family. Upon viral stimulation mammalian NLRX1 competes with RIG-I for IPS-1 interaction and has been identified as a negative regulator of RLR signaling.

Literature References
PubMed ID Title Journal Year
18200010 NLRX1 is a regulator of mitochondrial antiviral immunity

Moore, CB, Bergstralh, DT, Duncan, JA, Lei, Y, Morrison, TE, Zimmermann, AG, Accavitti-Loper, MA, Madden, VJ, Sun, L, Ye, Z, Lich, JD, Heise, MT, Chen, Z, Ting, JP

Nature 2008
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