Predicted chicken interferon beta promoter stimulator 1(IPS1) protein shows 27 and 31% amino acid sequence identity to its human and mouse orthologs respectively. Here we assume that chicken IPS1 behaves similar to its human counterpart upon viral stimulation.
In mammals, viral RNA binding to RLRs is believed to induce conformational changes, which unmask CARD regions of RIG-1 and MDA5. The CARDs of RLR interact with N- terminal CARD domain of mitochondria-bound adaptor protein - IPS-1, also known as VISA, MAVS or CARDIF [Yoneyama et al 2005, Saito et al 2007, Kawai et al 2005, Potter et al 2008].
Potter, JA, Randall, RE, Taylor, GL
Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB
Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O
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