In mammals, viral RNA binding to RLRs is believed to induce conformational changes, which unmask CARD regions of RIG-1 and MDA5. The CARDs of RLR interact with N- terminal CARD domain of mitochondria-bound adaptor protein - IPS-1, also known as VISA, MAVS or CARDIF [Yoneyama et al 2005, Saito et al 2007, Kawai et al 2005, Potter et al 2008].
Xu, LG, Shu, HB, Han, KJ, Wang, YY, Zhai, Z, Li, LY
Taylor, GL, Potter, JA, Randall, RE
Takeuchi, O, Ishii, KJ, Kumar, H, Sato, S, Kawai, T, Takahashi, K, Kato, H, Coban, C
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