In mammals, viral RNA binding to RLRs is believed to induce conformational changes, which unmask CARD regions of RIG-1 and MDA5. The CARDs of RLR interact with N- terminal CARD domain of mitochondria-bound adaptor protein - IPS-1, also known as VISA, MAVS or CARDIF [Yoneyama et al 2005, Saito et al 2007, Kawai et al 2005, Potter et al 2008].
Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB
Potter, JA, Randall, RE, Taylor, GL
Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O
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