Activated MDA5 binds IPS-1

Stable Identifier
Reaction [binding]
Gallus gallus
Related Species
Infectious bronchitis virus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Predicted chicken interferon beta promoter stimulator 1(IPS1) protein shows 27 and 31% amino acid sequence identity to its human and mouse orthologs respectively. Here we assume that chicken IPS1 behaves similar to its human counterpart upon viral stimulation.

In mammals, viral RNA binding to RLRs is believed to induce conformational changes, which unmask CARD regions of RIG-1 and MDA5. The CARDs of RLR interact with N- terminal CARD domain of mitochondria-bound adaptor protein - IPS-1, also known as VISA, MAVS or CARDIF [Yoneyama et al 2005, Saito et al 2007, Kawai et al 2005, Potter et al 2008].

Literature References
PubMed ID Title Journal Year
18307765 Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain

Potter, JA, Randall, RE, Taylor, GL

BMC Struct Biol 2008
16153868 VISA is an adapter protein required for virus-triggered IFN-beta signaling

Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB

Mol Cell 2005
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O

Nat Immunol 2005
Participant Of
This event is regulated
Inferred From
Cite Us!