IPS1 interacts with TRADD, RIP1 and FADD

Stable Identifier
Reaction [binding]
Gallus gallus
Related Species
Infectious bronchitis virus
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Mammalian IPS-1 was shown to interact with death domain (DD)-containing proteins FADD (Fas-associated death domain), RIP-1(receptor-interacting protein)and TRADD (TNFR-associated death domain) to mediate NFkB activation.

Literature References
PubMed ID Title Journal Year
15549108 A FADD-dependent innate immune mechanism in mammalian cells

Balachandran, S, Thomas, E, Barber, GN

Nature 2004
19295631 Death receptor signal transducers: nodes of coordination in immune signaling networks

Wilson, NS, Dixit, V, Ashkenazi, A

Nat Immunol 2009
18439848 TRADD protein is an essential component of the RIG-like helicase antiviral pathway

Michallet, MC, Meylan, E, Ermolaeva, MA, Vazquez, J, Rebsamen, M, Curran, J, Poeck, H, Bscheider, M, Hartmann, G, K├Ânig, M, Kalinke, U, Pasparakis, M, Tschopp, J

Immunity 2008
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O

Nat Immunol 2005
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