MEKK1 binds TRAF6

Stable Identifier
R-GGA-1227778
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
mitochondrial outer membrane, cytosol
ReviewStatus
5/5
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MEKK1 binds TRAF6
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Mammalian MEKK1 was reported to be involved to IPS-1/TRAF6 signaling pathway leading to NFkB activation, however the mechanism of virus-triggered MEKK1 activation remains unclear.

Predicted chicken MEKK1 shows 77% amino acid sequence identity to its human counterpart.

Literature References
PubMed ID Title Journal Year
9689078 MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

Dang, LC, Lee, FS, Peters, RT, Maniatis, T

Proc Natl Acad Sci U S A 1998
18984593 TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

Kobayashi, T, Kawai, T, Yoshioka, T, Yoshida, H, Takaesu, G, Yoshida, R, Yoshimura, A, Choi, Y, Akira, S, Okamoto, F

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
Inferred From
Interaction of MEKK1 with TRAF6 (Homo sapiens)
Authored
Shamovsky, V  (2011-01-05)
Reviewed
Garapati, P V  (2011-05-16)
Created
Shamovsky, V  (2011-03-10)
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