Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate

Stable Identifier
R-GGA-1227804
Type
Reaction
Species
Gallus gallus
Related Species
Infectious bronchitis virus
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Summation

Predicted chicken autophagy protein 5 (Atg5) and autophagy-related protein 12 (Atg12) show 90 and 58% amino acid sequence identity to their human counterparts respectively. In mammals, Atg5-Atg12 conjugate negatively regulates RLR signaling pathway in both resting as well as virus-triggered cells by direct interaction with caspase recruitment domains (CARDs) of RIG-I/MDA5 and IPS-1. Thus, the ATG5-ATG12 conjugate intercalate between the CARDs of RIG-I/MDA5 and IPS-1 and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses.

Literature References
PubMed ID Title Journal Year
17709747 The Atg5 Atg12 conjugate associates with innate antiviral immune responses

Jounai, N, Takeshita, F, Kobiyama, K, Sawano, A, Miyawaki, A, Xin, KQ, Ishii, KJ, Kawai, T, Akira, S, Suzuki, K, Okuda, K

Proc Natl Acad Sci U S A 2007
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