Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate

Stable Identifier
R-GGA-1227804
Type
Reaction
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
Locations in the PathwayBrowser
Summation

Predicted chicken autophagy protein 5 (Atg5) and autophagy-related protein 12 (Atg12) show 90 and 58% amino acid sequence identity to their human counterparts respectively. In mammals, Atg5-Atg12 conjugate negatively regulates RLR signaling pathway in both resting as well as virus-triggered cells by direct interaction with caspase recruitment domains (CARDs) of RIG-I/MDA5 and IPS-1. Thus, the ATG5-ATG12 conjugate intercalate between the CARDs of RIG-I/MDA5 and IPS-1 and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses.

Literature References
PubMed ID Title Journal Year
17709747 The Atg5 Atg12 conjugate associates with innate antiviral immune responses Proc Natl Acad Sci U S A 2007
Participants
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Inferred From