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ITCH homolog downregulates MDA5/IPS1 signaling

Stable Identifier
R-GGA-1227860
Type
Reaction
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
Locations in the PathwayBrowser
Summation

Predicted chicken ITCH shows 86% amino acid sequence identiti to its human ortholog. In mammals, ITCH, also known as AIP4 (atrophin 1-interacting protein-4), negatively regulates RLR signaling through Lys-48 linked polyubiquitination of IPS-1 resulting in IPS-1 proteasomal degradation.

Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 Nat Immunol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-ubiquitin ligase activity of ITCH [cytosol]
Physical Entity
Activity
Inferred From