Reactome: A Curated Pathway Database

ITCH homolog downregulates MDA5/IPS1 signaling

Stable Identifier
R-GGA-1227860
Type
Reaction
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
Locations in the PathwayBrowser
Summation

Predicted chicken ITCH shows 86% amino acid sequence identiti to its human ortholog. In mammals, ITCH, also known as AIP4 (atrophin 1-interacting protein-4), negatively regulates RLR signaling through Lys-48 linked polyubiquitination of IPS-1 resulting in IPS-1 proteasomal degradation.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-ubiquitin ligase activity of ITCH [cytosol] ITCH [cytosol] ubiquitin-ubiquitin ligase activity (0034450)
Inferred From