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PLK1 [cytosol]
Stable Identifier
R-GGA-164603
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
PLK1, F1NCX7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle Checkpoints (Gallus gallus)
Mitotic Spindle Checkpoint (Gallus gallus)
Amplification of signal from the kinetochores (Gallus gallus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Gallus gallus)
MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mad1 binds kinetochore (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Release of activated MAD2 from kinetochores (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Separation of Sister Chromatids (Gallus gallus)
ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mitotic Prometaphase (Gallus gallus)
EML4 and NUDC in mitotic spindle formation (Gallus gallus)
EML4 recruits NUDC to mitotic spindle (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Recruitment of NuMA to mitotic centrosomes (Gallus gallus)
Translocation of NuMA to the centrosomes (Gallus gallus)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Gallus gallus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Resolution of Sister Chromatid Cohesion (Gallus gallus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Kinetochore assembly (Gallus gallus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
PLK1 phosphorylates FIRMM at S744 (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
PPP1CC dephosphorylates PLK1 (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
AURKA Activation by TPX2 (Gallus gallus)
TPX2 binds AURKA at centrosomes (Gallus gallus)
Centrosome:AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Gallus gallus)
Centrosome:AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
TPX2 promotes AURKA autophosphorylation (Gallus gallus)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Gallus gallus)
Centrosome:AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome maturation (Gallus gallus)
Loss of proteins required for interphase microtubule organization from the centrosome (Gallus gallus)
Loss of C-Nap-1 from centrosomes (Gallus gallus)
cNAP-1 depleted centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Loss of Nlp from mitotic centrosomes (Gallus gallus)
Plk1-mediated phosphorylation of Nlp (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
centrosome containing phosphorylated Nlp [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Recruitment of mitotic centrosome proteins and complexes (Gallus gallus)
Recruitment of CDK11p58 to the centrosomes (Gallus gallus)
Centrosomes containing recruited CDK11p58 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Recruitment of Plk1 to centrosomes (Gallus gallus)
Centrosome associated Plk1 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Regulation of PLK1 Activity at G2/M Transition (Gallus gallus)
AJUBA binds centrosome-associated AURKA (Gallus gallus)
Centrosome:AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:AURKA:AJUBA [cytosol] (Gallus gallus)
Centrosome:AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
AJUBA facilitates AURKA autophosphorylation (Gallus gallus)
Centrosome:AURKA:AJUBA [cytosol] (Gallus gallus)
Centrosome:AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
AURKA phosphorylates PLK1 (Gallus gallus)
Centrosome:p-T288-AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
p-S252-BORA:PLK1 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
BORA binds PLK1 and AURKA (Gallus gallus)
Centrosome:p-T288-AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Gallus gallus)
Centrosome:p-T288-AURKA [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
p-S252-BORA:PLK1 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Regulation of mitotic cell cycle (Gallus gallus)
APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Gallus gallus)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Gallus gallus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Gallus gallus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Organelle biogenesis and maintenance (Gallus gallus)
Cilium Assembly (Gallus gallus)
Anchoring of the basal body to the plasma membrane (Gallus gallus)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)
basal body:transition zone proteins [cytosol] (Gallus gallus)
basal body [cytosol] (Gallus gallus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Gallus gallus)
basal body:transition zone proteins [cytosol] (Gallus gallus)
basal body [cytosol] (Gallus gallus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Gallus gallus)
basal body:transition zone proteins [cytosol] (Gallus gallus)
basal body [cytosol] (Gallus gallus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Recruitment of transition zone proteins (Gallus gallus)
basal body [cytosol] (Gallus gallus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
basal body:transition zone proteins [cytosol] (Gallus gallus)
basal body [cytosol] (Gallus gallus)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
The distal appendage proteins recruit TTBK2 (Gallus gallus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Gallus gallus)
mother centriole:C2CD3 [cytosol] (Gallus gallus)
mother centriole [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Gallus gallus)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Gallus gallus)
mother centriole:C2CD3 [cytosol] (Gallus gallus)
mother centriole [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate Formins (Gallus gallus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
PLK1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NCX7
Gene Names
PLK1
Reference Genes
ENSEMBL:ENSGALG00000006110
ENSEMBL:ENSGALG00010017105.1 PLK1
Other Identifiers
416575
GO:0000070
GO:0000086
GO:0000122
GO:0000132
GO:0000166
GO:0000228
GO:0000278
GO:0000281
GO:0000287
GO:0000775
GO:0000776
GO:0000779
GO:0000785
GO:0000795
GO:0000910
GO:0000922
GO:0000940
GO:0001578
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005819
GO:0005856
GO:0005876
GO:0006281
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007049
GO:0007052
GO:0007059
GO:0007094
GO:0007095
GO:0007098
GO:0007163
GO:0007346
GO:0008017
GO:0008092
GO:0010800
GO:0010997
GO:0012501
GO:0015630
GO:0016301
GO:0016310
GO:0016321
GO:0016567
GO:0016740
GO:0019901
GO:0022414
GO:0023052
GO:0030071
GO:0030163
GO:0030496
GO:0031648
GO:0032436
GO:0032465
GO:0033365
GO:0034451
GO:0036211
GO:0042802
GO:0043066
GO:0043226
GO:0045143
GO:0045184
GO:0045862
GO:0051081
GO:0051233
GO:0051301
GO:0061024
GO:0070194
GO:0071168
GO:0090435
GO:0097431
GO:0097681
GO:0140013
GO:0140014
GO:0140096
GO:1901673
GO:1904776
GT_A_87_P036300
GgaAffx.12701.1.S1_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
mother centriole [cytosol] (Gallus gallus)
Centrosome associated Plk1 [cytosol] (Gallus gallus)
Nlp-depleted centrosome [cytosol] (Gallus gallus)
centrosome containing phosphorylated Nlp [cytosol] (Gallus gallus)
cNAP-1 depleted centrosome [cytosol] (Gallus gallus)
p-S252-BORA:PLK1 [cytosol] (Gallus gallus)
centrosome [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
as an input of
Recruitment of Plk1 to centrosomes (Gallus gallus)
BORA binds PLK1 and AURKA (Gallus gallus)
as an output of
PPP1CC dephosphorylates PLK1 (Gallus gallus)
as a member of
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Gallus gallus)
Other forms of this molecule
PLK1 [nucleoplasm]
phospho-PLK1 [cytosol]
phospho-PLK1 [nucleoplasm]
Inferred From
PLK1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000166851
Ensembl
ENSGALT00010041287
,
ENSGALG00010017105
,
ENSGALP00010024174
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